Successful treatment of Colombian cutaneous leishmaniasis with four injections of pentamidine.

Author: BermanJ, BuffetP, GroglM, SotoJ

Paper Details 
Original Abstract of the Article :
We previously found that 2 mg of pentamidine isethionate/kg, administered every other day in seven injections, was 95% curative for Colombian cutaneous leishmaniasis. However, 17% of the patients had to prematurely terminate therapy due to drug toxicity and another 30% had mild-to-moderate toxic cli...See full text at original site
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引用元:
https://doi.org/10.4269/ajtmh.1994.50.107

データ提供:米国国立医学図書館(NLM)

A Quest for Optimal Treatment: Pentamidine for Colombian Cutaneous Leishmaniasis

The world of tropical diseases, like a vast and unforgiving desert, presents numerous challenges for healthcare professionals. This study investigates the effectiveness of pentamidine isethionate, a promising drug for the treatment of Colombian cutaneous leishmaniasis, a parasitic infection that plagues many regions. The authors, akin to desert explorers seeking the most efficient route, aimed to optimize pentamidine's therapeutic efficacy while minimizing potential side effects. Their research, like a series of carefully planned expeditions, explored various dosage regimens, ultimately pinpointing a four-injection, every-other-day schedule of 3 mg/kg as the most effective and tolerable regimen. This regimen, like a well-provisioned caravan, offers a high cure rate while mitigating the risk of severe side effects, making it a competitive option for treating this debilitating disease. The study's findings have far-reaching implications, highlighting the potential for this regimen to be adopted for treating cutaneous leishmaniasis in other endemic areas, offering hope to patients in regions facing similar challenges.

A Beacon of Hope in the Fight Against Leishmaniasis

The study's results illuminate the potential of pentamidine isethionate as a potent weapon against Colombian cutaneous leishmaniasis. This optimized regimen, like a shimmering oasis in the desert, offers a viable treatment option with a high cure rate and reduced toxicity, improving the quality of life for patients. The study's findings serve as a reminder that even in the most challenging medical landscapes, there is always hope for finding effective solutions.

Navigating the Desert of Leishmaniasis Treatment

This research underscores the importance of continuous exploration in the field of tropical medicine. By optimizing treatment strategies and developing innovative therapeutic approaches, we can provide effective and safe care for patients battling these often neglected diseases. The study's findings serve as a compass guiding us towards a more effective and compassionate approach to treating leishmaniasis.

Dr.Camel's Conclusion

This research journey through the desert of leishmaniasis treatment unveils a promising regimen for pentamidine isethionate, offering a balanced approach to efficacy and tolerability. This discovery, like a precious oasis, provides hope and relief to patients, paving the way for a brighter future in the fight against this debilitating disease.

Date :
  1. Date Completed 1994-03-08
  2. Date Revised 2022-04-08
Further Info :

Pubmed ID

8304565

DOI: Digital Object Identifier

10.4269/ajtmh.1994.50.107

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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