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Acute changes in glucose uptake after treatment: the effects of carmustine (BCNU) on human glioblastoma multiforme.

Author: CohenJ D, HansonJ M, LevineR L, MehtaM P, NicklesR J, RozentalJ M

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

This study investigated the use of PET-FDG scans, a type of imaging test, to predict survival in patients with glioblastoma multiforme, an aggressive brain tumor, who received chemotherapy with BCNU. The study found that the percentage change in FDG uptake between baseline and 24 hours after treatment was a significant prognostic indicator, with larger changes associated with shorter survival.
Paper Details　
Original Abstract of the Article :
Sequential positron emission tomographic scans with [18F]-2-fluorodeoxyglucose (PET-FDG) were performed on 6 patients with glioblastoma multiforme who were treated with adjuvant BCNU. Scans were acquired before and 24 hours after BCNU. All patients had prior brain irradiation. Ratios between the max...See full text at original site
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引用元：
https://doi.org/10.1007/BF01050264

データ提供：米国国立医学図書館（NLM）

A Glimpse into the Metabolic Landscape of Glioblastoma Multiforme

This study investigates the impact of carmustine (BCNU), a chemotherapy drug, on glucose uptake in patients with glioblastoma multiforme (GBM), an aggressive brain tumor. The researchers employed positron emission tomography (PET) with [18F]-2-fluorodeoxyglucose (FDG) to measure glucose uptake in GBM patients before and after BCNU treatment. They observed that the extent of change in glucose uptake after BCNU treatment was associated with survival outcomes. Their findings highlight the potential of PET-FDG imaging to monitor treatment response and predict survival in GBM patients.

Unmasking the Metabolic Dynamics of Brain Tumors

The study reveals a correlation between changes in glucose uptake after BCNU treatment and survival outcomes in patients with GBM. The researchers found that patients who exhibited the largest decreases in glucose uptake after treatment had the shortest survival times. This finding suggests that PET-FDG imaging can serve as a valuable tool for monitoring treatment response and potentially predicting survival in GBM patients.

Monitoring Treatment Response

This study underscores the importance of monitoring treatment response in patients with GBM. PET-FDG imaging can provide valuable information on the metabolic activity of the tumor, potentially aiding in treatment decisions and prognostic assessment. Regular monitoring of glucose uptake can help healthcare professionals evaluate the effectiveness of treatment and identify potential resistance or progression of the disease.

Dr.Camel's Conclusion

This research sheds light on the metabolic dynamics of glioblastoma multiforme and the potential of PET-FDG imaging to monitor treatment response and predict survival. The study reveals a correlation between changes in glucose uptake after BCNU treatment and survival outcomes, highlighting the importance of monitoring these metabolic changes. This research contributes to the ongoing efforts to optimize GBM treatment strategies and improve patient outcomes.

Date :
  1. Date Completed 1993-04-22
  2. Date Revised 2019-09-09
Further Info :

Pubmed ID

8384254

DOI: Digital Object Identifier

10.1007/BF01050264

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PICO Info
in preparation
Languages

English

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