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Oral versus transdermal hormone replacement therapy.

Author: CrookD, GodslandI F, LeesB, StevensonJ C, WhiteheadM I

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

In a study of 96 postmenopausal women, both oral and transdermal hormone replacement therapy (HRT) prevented bone loss and generally improved blood lipid levels. However, transdermal HRT produced more favorable metabolic effects than oral HRT. Oral HRT was associated with worsened glucose tolerance and increased insulin secretion, while transdermal HRT did not. Both forms of HRT had similar effectiveness in preventing osteoporosis, but transdermal HRT may be preferable due to its more favorable metabolic profile.
Paper Details　
Original Abstract of the Article :
Loss of ovarian function at the menopause results in an increased risk for cardiovascular disease and osteoporosis. Hormone replacement therapy (HRT) in postmenopausal women may reduce or remove this increased risk. The high hepatic bolus seen with oral steroid administration, which may produce unwa...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/8499957

データ提供：米国国立医学図書館（NLM）

Oral Versus Transdermal Hormone Replacement Therapy

This research examines the impact of [hormone replacement therapy (HRT)] on [the metabolic health of postmenopausal women], comparing [oral and transdermal HRT] in a [long-term study]. The study analyzed [various metabolic markers] and [bone health] over [three years] to evaluate [the relative benefits and risks] of [each HRT route]. The results provide insights into [the potential impact of HRT on cardiovascular health] and [bone density] in [postmenopausal women].

Transdermal HRT Shows Promise for Metabolic Health in Postmenopausal Women

This study suggests that [transdermal HRT] may be [a more favorable option than oral HRT] for [postmenopausal women] seeking to improve their [metabolic health]. The study found that [transdermal HRT] produced [generally favorable lipid and lipoprotein changes], while [oral HRT] resulted in [deterioration in glucose tolerance] and [increased insulin secretion]. The research also showed that [both HRT regimens were effective in preventing bone loss].

Navigating the HRT Landscape: A Personal Journey

This research provides valuable information for [postmenopausal women] considering [HRT]. It emphasizes the importance of [carefully weighing the potential benefits and risks] of [each HRT route] to make [the best decision for their individual needs]. The study highlights that [transdermal HRT] may be a more beneficial choice for women who are concerned about [potential metabolic side-effects], while [oral HRT] may be a better option for women who prioritize [convenience].

Dr. Camel's Conclusion

Just as a desert traveler chooses a path based on the terrain, [postmenopausal women] need to consider [the unique aspects of each HRT route] to find the most suitable option. This research guides us through the dunes of HRT options, highlighting [the potential advantages and disadvantages] of each path, allowing us to make informed choices for our health and well-being.
Date :
  1. Date Completed 1993-07-01
  2. Date Revised 2022-12-07
Further Info :

Pubmed ID

8499957

DOI: Digital Object Identifier

8499957

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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