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Comparison of nisoldipine and nifedipine as additional treatment in hypertension inadequately controlled by atenolol.

Author: EarleK A, HoffbrandB I, NievelJ G, RestrickL J, SimmondsN J

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Nisoldipine was as effective and well-tolerated as nifedipine in treating hypertension in patients inadequately controlled on atenolol.
Paper Details　
Original Abstract of the Article :
Twenty-eight patients (11 Caucasian, 17 black) whose blood pressure was more than 160/96 mmHg after 4 weeks on placebo added to atenolol 100 mg/day were randomly given, in addition, nisoldipine 10 mg or nifedipine 20 mg each twice a day for 8 weeks in a double-blind cross-over study. There was a sta...See full text at original site
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引用元：
https://doi.org/10.1136/pgmj.69.808.117

データ提供：米国国立医学図書館（NLM）

Nisoldipine vs. Nifedipine: A Comparison of Calcium Channel Blockers for Hypertension

[Hypertension] is a significant health concern affecting millions worldwide. This study compares the effectiveness of [nisoldipine] and [nifedipine], two [calcium channel blockers], as additional treatments for hypertension inadequately controlled by [atenolol]. The researchers conducted a double-blind crossover study to compare the efficacy and safety of nisoldipine and nifedipine in patients with hypertension.

Finding the Right Path to Lower Blood Pressure

The study found that both [nisoldipine] and [nifedipine] effectively lowered blood pressure in patients with hypertension inadequately controlled by [atenolol]. However, [nisoldipine] was associated with fewer adverse effects. It's like navigating the desert of hypertension, where choosing the right path can make all the difference in reaching a stable and healthy destination.

Tailoring Treatment for Individual Needs

This study emphasizes the importance of considering individual patient characteristics and potential side effects when choosing a [calcium channel blocker] for hypertension treatment. [Nisoldipine], with its higher coronary vascular selectivity and less negative inotropism, may be a suitable option for patients with impaired left ventricular function. It's like having a diverse range of desert plants, each with unique properties and benefits, allowing us to choose the most appropriate solution for specific needs.

Dr.Camel's Conclusion

This research highlights the potential of [nisoldipine] as a safe and effective [calcium channel blocker] for treating hypertension, particularly in patients with impaired left ventricular function. It underscores the importance of considering individual patient characteristics and potential side effects when choosing a medication for hypertension management.

Date :
  1. Date Completed 1993-07-07
  2. Date Revised 2022-12-07
Further Info :

Pubmed ID

8506191

DOI: Digital Object Identifier

10.1136/pgmj.69.808.117

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・Effects of nisoldipine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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