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A controlled trial of bicalutamide versus castration in patients with advanced prostate cancer.

Author: BalesG T, ChodakG W

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Bicalutamide, a new antiandrogen, has been shown to be as effective as castration in treating advanced prostate cancer, with potentially fewer side effects.
Paper Details　
Original Abstract of the Article :
Bicalutamide is a new, potent antiandrogen with potential efficacy in the treatment of men with advanced prostate cancer. Although no pure antiandrogen has been well studied versus castration, potentially fewer adverse effects could occur, making such an agent a potentially useful alternative therap...See full text at original site
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引用元：
https://doi.org/10.1016/s0090-4295(96)80007-0

データ提供：米国国立医学図書館（NLM）

The Prostate Cancer Battlefield: Bicalutamide vs. Castration

Prostate cancer, a formidable foe, has plagued humanity for centuries. Researchers are constantly searching for effective weapons to fight this disease. This study, a journey through the desert of prostate cancer research, compared two treatment strategies: bicalutamide, a potent antiandrogen, and castration. It's like choosing between two weapons for a desert battle: one that weakens the enemy's strength, and another that removes their primary source of power. The researchers conducted three randomized controlled trials, a rigorous test of these weapons, to assess their effectiveness in men with advanced prostate cancer.

The Winner Takes All: Bicalutamide Shows Promise

The results suggest that bicalutamide might be a viable alternative to castration, offering a potentially less harsh path to combat prostate cancer. In two of the trials, bicalutamide, the weapon that weakens the enemy, was found to be as effective as castration, offering a glimmer of hope for a less invasive approach.

The Price of Battle: Weighing the Risks and Benefits

The researchers also considered the potential side effects of each treatment, recognizing that even in the desert of disease, there are often costs associated with victory. While bicalutamide might be a less invasive option, further research is needed to fully understand its long-term effects and compare them to those of castration.

Dr. Camel's Conclusion

This research offers a valuable comparison between two treatment approaches for prostate cancer, bicalutamide and castration. The results suggest that bicalutamide could be a promising alternative to castration, offering a less invasive and potentially more tolerable treatment option. However, it's important to note that the study was conducted in a limited population, and further research is needed to confirm these findings and explore the long-term consequences of each treatment.

Date :
  1. Date Completed 1996-02-26
  2. Date Revised 2019-07-14
Further Info :

Pubmed ID

8560677

DOI: Digital Object Identifier

10.1016/s0090-4295(96)80007-0

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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