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Effects of benztropine on behavioral and toxic effects of cocaine: comparison with atropine and the selective dopamine uptake inhibitor 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenyl-propyl)-piperazine.

Author: AcriJ B, SiedleckB K, WitkinJ M

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Benztropine, an antiparkinson agent, showed a unique behavioral and toxicity profile compared to classic dopamine uptake blockers. It stimulated locomotor activity but did not enhance the stimulant effects of cocaine, unlike GBR 12935. Benztropine did not reproduce the discriminative stimulus effects of cocaine, but GBR 12935 did, suggesting potential for benztropine in cocaine dependence treatment.
Paper Details　
Original Abstract of the Article :
Behavioral effects of cocaine that are relevant to its abuse have been associated with pharmacological actions at the dopamine uptake carrier. Benztropine (Cogentin) is an antiparkinson agent that has limited abuse despite its ability to block dopamine uptake, and has been suggested as a candidate f...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/8613919

データ提供：米国国立医学図書館（NLM）

The Desert of Cocaine Addiction: Exploring the Potential of Benztropine as a Treatment Option

The journey through the desert of cocaine addiction can be a perilous and often hopeless one, with individuals struggling to escape the clutches of this powerful drug. This study investigates the potential of benztropine, an antiparkinsonian agent, as a treatment for cocaine dependence. The researchers compared the behavioral and toxic effects of benztropine to those of atropine and GBR 12935, a selective dopamine uptake inhibitor, to understand its unique pharmacological profile.

A New Oasis: Benztropine Shows Promise as a Treatment for Cocaine Dependence

The study found that benztropine had a distinct behavioral and toxicity profile compared to classical dopamine uptake blockers. It did not enhance the locomotor stimulant effects of cocaine, nor did it fully reproduce the discriminative stimulus effects of cocaine. These findings suggest that benztropine may have a potential role in treating cocaine dependence, potentially offering a safer and more effective alternative to traditional treatments.

Navigating the Desert of Addiction: Exploring Innovative Treatment Approaches

This research highlights the importance of exploring innovative treatment approaches for cocaine addiction, a condition that continues to devastate individuals and families worldwide. The study's findings suggest that benztropine may offer a promising new avenue for treating cocaine dependence, warranting further investigation and clinical trials to assess its effectiveness and safety.

Dr.Camel's Conclusion

This study provides a beacon of hope in the desert of cocaine addiction, suggesting that benztropine may hold promise as a novel treatment option. By exploring new avenues for treatment and understanding the unique pharmacological properties of benztropine, we can continue to develop more effective and compassionate approaches to addressing this challenging public health issue.

Date :
  1. Date Completed 1996-06-06
  2. Date Revised 2016-11-23
Further Info :

Pubmed ID

8613919

DOI: Digital Object Identifier

8613919

Related Literature

Article Analysis
・Effects of benztropine
SNS
PICO Info
in preparation
Languages

English

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