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Differential genetic mediation of sensitivity to morphine in genetic models of opiate antinociception: influence of nociceptive assay.

Author: BelknapJ K, KestB, MogilJ S, SadowskiB

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Overview

This study compared the nociceptive and antinociceptive sensitivities of four genetic mouse models in four major nociceptive assays. Results showed high dissociation between these models, suggesting different underlying mechanisms. Morphine had different effects on nociception, potentially involving separate, genetically dissociated mechanisms. A striking finding was an inverse relationship between morphine antinociceptive sensitivity in the hot-plate and acetic acid abdominal constriction tests in HA/LA and HAR/LAR mice.
Paper Details　
Original Abstract of the Article :
Several genetic mouse models of opiate sensitivity have been identified or produced in an attempt to investigate mechanisms underlying individual variation in responses to opiate drugs like morphine. The major models in use presently are the DBA/2 (DBA) versus C57BL/6 (C57) inbred strains, the recom...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/8632319

データ提供：米国国立医学図書館（NLM）

Genetic Influence on Morphine Sensitivity in Different Nociceptive Assays

Think of different nociceptive assays like different types of sand dunes, each responding differently to the same force. This research investigates the influence of genetic background on morphine sensitivity in different nociceptive assays using four genetic mouse models. The study evaluated morphine antinociceptive responses in the hot-plate, tail-flick, acetic acid abdominal constriction, and formalin tests. The results show significant differences in morphine sensitivity across the genetic models and nociceptive assays, highlighting the complex genetic and physiological mechanisms underlying pain perception and morphine response.

Genetic Diversity and Morphine Sensitivity: A Complex Relationship

This study reveals the complex interplay between genetics and pain perception, demonstrating that morphine sensitivity can vary significantly depending on the genetic background and the specific nociceptive assay used. These findings emphasize the need for personalized approaches to pain management, considering individual genetic differences.

Understanding Pain: Tailoring Treatment Strategies

Pain perception and response to analgesics can vary widely among individuals. This research underscores the importance of considering individual factors, including genetics, when managing pain. Working with a healthcare professional to develop a personalized pain management plan that addresses your specific needs can improve your quality of life.

Dr. Camel's Conclusion

This research provides valuable insights into the complex relationship between genetics and morphine sensitivity in different nociceptive assays. The study's findings demonstrate that pain perception and analgesic response are influenced by a multitude of factors, highlighting the need for personalized approaches to pain management. With continued research, we can gain a deeper understanding of the mechanisms underlying pain and develop more effective strategies for its treatment.
Date :
  1. Date Completed 1996-07-03
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

8632319

DOI: Digital Object Identifier

8632319

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Languages

English

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