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[Prevention of osteoporosis: estrogen substitution paradigm].

Author: LangeS, PaeslerE, RichterK

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Overview

While many doctors believe that hormone replacement therapy (HRT) effectively prevents osteoporosis-related fractures in postmenopausal women, a closer look at studies suggests that the evidence is weaker than commonly thought. There have been no randomized trials specifically studying HRT's effect on hip fractures, the most serious consequence of osteoporosis. Observational studies have shown a protective effect, but the strength of this effect is inversely related to the quality of the study design. Therefore, a selection bias may be present, with healthier women potentially being more likely to use HRT. Randomized controlled trials are crucial to prove the effectiveness of HRT, and observational studies alone are not sufficient, regardless of how convincing they may seem.
Paper Details　
Original Abstract of the Article :
There is an increasing belief among most physicians that hormone replacement therapy (HRT) is unquestionable efficacious to prevent osteoporotic fractures in women after the menopause. However, an analysis of the studies which are regarded as efficacy proof of HRT concerning the prevention of hip fr...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/8881083

データ提供：米国国立医学図書館（NLM）

Estrogen Substitution and Osteoporosis: A Desert of Uncertainty

Osteoporosis is a prevalent condition, particularly in women after menopause. This study focuses on hormone replacement therapy (HRT) and its efficacy in preventing osteoporotic fractures. The authors challenge the prevailing belief that HRT is an unquestionable solution, highlighting the need for more robust evidence and rigorous research.

The Illusion of a Desert Oasis: HRT for Osteoporosis

The researchers scrutinized the studies that support the use of HRT for preventing hip fractures, the most serious manifestation of osteoporosis. They found that the data is weaker than generally perceived, lacking randomized controlled trials. The protective effect observed in observational studies is inversely related to the methodological quality of the studies. This means that the evidence for HRT's effectiveness might be an illusion, like a mirage shimmering in the desert.

Navigating the Desert: Seeking Robust Evidence for Osteoporosis Treatment

This study serves as a stark reminder that we cannot rely on observational studies alone for evidence-based decision making. The research community needs to conduct rigorous randomized controlled trials to determine the true efficacy of HRT in preventing osteoporotic fractures. This is like embarking on a journey through the desert, carefully navigating the landscape to find the most reliable path to safe and effective treatment.

Dr.Camel's Conclusion

This study emphasizes the need for robust scientific evidence when assessing the efficacy of treatments for osteoporosis. While HRT may offer potential benefits, we need to carefully evaluate the evidence through rigorous research. As we journey through the desert of osteoporosis research, we must be vigilant, avoiding the mirage of assumptions and seeking the oasis of proven efficacy.

Date :
  1. Date Completed 1996-12-17
  2. Date Revised 2017-11-16
Further Info :

Pubmed ID

8881083

DOI: Digital Object Identifier

8881083

SNS
PICO Info
in preparation
Languages

German

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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