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Mercaptopurine in childhood leukaemia: the effects of dose escalation on thioguanine nucleotide metabolites.

Author: LennardL, LilleymanJ S, WelchJ

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Dose escalation of mercaptopurine in children tolerant of 100% dosage resulted in higher peak thioguanine nucleotide concentrations.
Paper Details　
Original Abstract of the Article :
The current U.K. trial protocol (UKALL XI) for childhood lymphoblastic leukaemia demands mercaptopurine (MP) dose escalation in children who tolerate daily 75 mg/m2 MP (100% dose) without cytopenias. The previous trial (UKALL X) did not. MP metabolism was studied in a group of UKALL XI children (n =...See full text at original site
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引用元：
https://doi.org/10.1046/j.1365-2125.1996.44921.x

データ提供：米国国立医学図書館（NLM）

Dose Escalation and Thioguanine Nucleotide Metabolites in Childhood Leukemia

Childhood leukemia, a serious disease that affects blood-forming cells, can feel like a vast and daunting desert. Mercaptopurine (MP), a chemotherapy medication, is a crucial tool in treating this condition. However, finding the right dose for each patient can be a delicate balancing act, aiming to maximize therapeutic efficacy while minimizing side effects. This research investigates the effects of MP dose escalation on thioguanine nucleotide (TGN) metabolites in children with leukemia, looking for ways to optimize MP therapy.

Dose Escalation: A Key to Optimizing MP Therapy

The researchers found that MP dose escalation in children who tolerated a standard dose led to higher TGN concentrations. This finding suggests that carefully increasing the dose of MP could potentially improve therapeutic efficacy, potentially leading to better treatment outcomes. However, it's essential to carefully monitor patients for side effects and adjust the dose accordingly.

Navigating the Desert of Childhood Leukemia: A Collaborative Journey

Navigating the desert of childhood leukemia requires a collaborative approach involving parents, healthcare professionals, and researchers. Open communication and a shared understanding of the treatment plan are essential for ensuring the best possible outcome for the child. Remember, you're not alone in this journey, and there are resources available to support you and your family.

Dr.Camel's Conclusion

This research provides valuable insights into the effects of MP dose escalation in childhood leukemia. The study suggests that careful dose escalation could potentially optimize MP therapy, leading to improved treatment outcomes. However, this research highlights the need for careful monitoring and personalized treatment plans to ensure that each child receives the optimal dose of MP.
Date :
  1. Date Completed 1997-02-18
  2. Date Revised 2019-05-12
Further Info :

Pubmed ID

8904630

DOI: Digital Object Identifier

10.1046/j.1365-2125.1996.44921.x

SNS
PICO Info
in preparation
Languages

English

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