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Effects of microtubule inhibitors-taxol, vinblastine and estramustine on the growth and p53 gene expression in the hormone independent human prostatic JCA-1 cells.

Author: AnS, DarbyE, HsiehT C, MallouhC, NgC, WuJ M

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study found that antimicrotubule agents taxol, vinblastine, and estramustine reduced cell growth and p53 gene expression in JCA-1 prostate cells, suggesting their potential as complementary treatment modalities for hormonally independent prostate cancer.
Paper Details　
Original Abstract of the Article :
Treatment of the JCA-1 prostate cells with different concentrations of microtubule inhibitors-taxol (paclitaxel) vinblastine, and estramustine-was accompanied by reduced cell growth and, correspondingly, characteristic morphological changes. The reduction of cellular proliferation was unlikely to be...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

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引用元：
https://pubmed.ncbi.nlm.nih.gov/9042236

データ提供：米国国立医学図書館（NLM）

Microtubule Inhibitors for Prostate Cancer: A Promising New Direction

The fight against prostate cancer, like a desert battle, requires a multi-pronged approach. This study investigates the effects of microtubule inhibitors, such as taxol (paclitaxel), vinblastine, and estramustine, on the growth and p53 gene expression of hormone-independent human prostatic JCA-1 cells.

Microtubule Inhibitors' Potential for Prostate Cancer Treatment

The study found that microtubule inhibitors effectively reduced cell growth in JCA-1 cells, suggesting their potential as complementary treatment modalities for patients with hormonally independent prostate cancer.

New Strategies for Fighting Prostate Cancer

The discovery of microtubule inhibitors' efficacy against hormone-independent prostate cancer provides new hope for patients seeking effective treatments. It's like finding a new oasis in a seemingly barren desert, offering a source of hope and potential relief.

Dr.Camel's Conclusion

This study highlights the potential of microtubule inhibitors as a promising new approach for treating hormone-independent prostate cancer. Further research is needed to optimize their use and explore their potential in combination therapies, but microtubule inhibitors offer a potentially valuable tool in the fight against this challenging disease.

Date :
  1. Date Completed 1997-03-27
  2. Date Revised 2015-11-19
Further Info :

Pubmed ID

9042236

DOI: Digital Object Identifier

9042236

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Article Analysis
・Effects of estramustine
SNS
PICO Info
in preparation
Languages

English

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