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Fenfluramine and methylphenidate in children with mental retardation and borderline IQ: clinical effects.

Author: AmanM G, KernR A, OsborneP, RojahnJ, TumuluruR, del MedicoV

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Methylphenidate and fenfluramine were compared for their effectiveness in treating children with mental retardation or borderline IQ and ADHD. Fenfluramine was more effective than methylphenidate on several parent and teacher subscales. The highest dose of fenfluramine produced more behavior compliance but apparently at the cost of cognitive efficiency.
Paper Details　
Original Abstract of the Article :
A double-blind, placebo-controlled, crossover study of methylphenidate (0.4 mg/kgday) and different doses of fenfluramine (1.0, 1.5, or 2.0 mg/g/day) in children with mental retardation or borderline IQ and ADHD was conducted. Parents, teachers, examiners, and physicians rated the children. There we...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/9083608

データ提供：米国国立医学図書館（NLM）

Exploring Treatment Options for ADHD in Children with Mental Retardation

The study investigated the effectiveness of two medications, methylphenidate and fenfluramine, in treating attention-deficit hyperactivity disorder (ADHD) in children with mental retardation or borderline IQ. The study employed a double-blind, placebo-controlled, crossover design, allowing researchers to carefully evaluate the effects of each medication compared to a placebo. The researchers compared the efficacy of each drug and examined the side effects associated with their use.

Fenfluramine Shows Promise, but With Potential Risks

The research found that both methylphenidate and fenfluramine showed positive effects in treating ADHD symptoms in this population. Fenfluramine, however, was found to be more effective on certain aspects of behavior and cognition compared to methylphenidate. However, the study also noted potential neurotoxic effects associated with higher doses of fenfluramine, highlighting the importance of cautious and gradual dosage adjustments to minimize the risks.

Navigating Treatment Decisions

This research offers valuable insights for healthcare professionals when treating children with ADHD and mental retardation. The study suggests that both methylphenidate and fenfluramine can be effective treatments, but the potential for neurotoxicity with fenfluramine requires careful monitoring and dosage adjustments. Understanding the specific needs of each child and weighing the benefits and risks of each medication is crucial for making informed treatment decisions.

Dr. Camel's Conclusion

Like a camel navigating a winding desert trail, finding the right medication for ADHD in children with mental retardation requires careful consideration and a balanced approach. This study sheds light on the potential benefits and risks associated with different treatment options, emphasizing the need for individualized care and close monitoring.

Date :
  1. Date Completed 1997-07-15
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

9083608

DOI: Digital Object Identifier

9083608

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in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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