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Responses of HDL subclasses, Lp(A-I) and Lp(A-I:A-II) levels and lipolytic enzyme activities to continuous oral estrogen-progestin and transdermal estrogen with cyclic progestin regimens in postmenopausal women.

Author: KahriJ, LahdenperäS, LappiM, LuotolaH, PuolakkaJ, PyöräläT, TaskinenM R, Tilly-KiesiM

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

A study of 70 postmenopausal women compared the effects of two hormone replacement therapy (HRT) regimens on HDL cholesterol levels and related components. The first regimen (E2/NETA) used continuous oral estradiol and norethisterone acetate. The second regimen (E2/MPA) used transdermal estradiol and cyclic medroxyprogesterone acetate. After 12 months, the E2/NETA group experienced a significant decrease in HDL2 cholesterol and a reduction in all HDL subclasses. The E2/MPA group showed a smaller decrease in HDL2 and HDL3 cholesterol and no significant changes in HDL subclass composition. Both regimens had minimal effects on apolipoproteins and lipolytic enzymes. These findings suggest that both HRT regimens can affect HDL levels, but the specific changes may vary depending on the hormones used.
Paper Details　
Original Abstract of the Article :
Seventy postmenopausal women took part in the study. Subjects received either continuous oral 17 beta-estradiol 2 mg/day combined with norethisterone acetate 1 mg/day (E2/NETA, Kliogest) or transdermal treatment consisting of 28 day cycles with patches delivering 17 beta-estradiol 50 micrograms/day ...See full text at original site
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引用元：
https://doi.org/10.1016/s0021-9150(96)06036-4

データ提供：米国国立医学図書館（NLM）

Hormonal Effects on HDL Subclasses: Navigating the Complex Landscape of Cholesterol

Cholesterol, a vital component of our cell membranes, plays a complex role in our health. High-density lipoprotein (HDL), often referred to as “good cholesterol,” is responsible for transporting excess cholesterol from the body. This research investigates the effects of different hormone replacement therapies (HRT) on HDL subclasses, exploring the impact of these treatments on cholesterol metabolism. The researchers studied two HRT regimens: continuous oral estrogen-progestin and transdermal estrogen with cyclic progestin. They observed that both regimens had significant effects on HDL subclasses, suggesting a complex relationship between hormones and cholesterol metabolism, much like the intricate interplay of wind and sand shaping the landscape of a desert.

Navigating the Cholesterol Landscape: Insights into HRT's Impact

This research provides valuable insights into the effects of HRT on HDL subclasses. The study found that both HRT regimens had distinct effects on HDL subclasses, highlighting the need for a personalized approach to HRT. This understanding is akin to navigating a complex desert landscape, where different routes offer unique advantages and disadvantages. By carefully considering the individual needs and responses of patients, we can tailor HRT regimens to optimize cholesterol management.

Optimizing Cholesterol Management: A Personalized Approach to HRT

The findings of this study underscore the importance of individualized HRT regimens, taking into account the patient's specific needs and responses. This is like customizing a camel caravan for a journey through a diverse desert landscape, ensuring that each traveler is equipped for the unique challenges ahead. By adopting a more personalized approach to HRT, we can better manage cholesterol levels and optimize overall health.

Dr.Camel's Conclusion

This research, like a wise camel navigating the shifting sands of cholesterol metabolism, highlights the importance of understanding the complex relationship between hormones and cholesterol. By carefully considering the individual needs of patients and tailoring HRT regimens accordingly, we can create a more personalized and effective approach to managing cholesterol levels.

Date :
  1. Date Completed 1997-07-14
  2. Date Revised 2019-07-18
Further Info :

Pubmed ID

9105568

DOI: Digital Object Identifier

10.1016/s0021-9150(96)06036-4

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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