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Androgen receptor gene mutations in prostate cancer. Implications for disease progression and therapy.

Author: BartschG, CronauerM V, CuligZ, HittmairA, HobischA, KlockerH, RadmayrC

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Androgen receptor mutations have been found in human prostatic tumours. These mutations may explain, at least in part, the antiandrogen withdrawal syndrome. Further studies on androgen receptor alterations in prostate cancer should focus on metastatic specimens obtained from the late stages of this disease.
Paper Details　
Original Abstract of the Article :
Recent studies indicate that androgen receptors are present in all histological types of prostatic tumours, in relapsed prostatic carcinomas and in tumour metastases, even those obtained from patients in whom endocrine therapy was unsuccessful. Several research groups have asked whether structurally...See full text at original site
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引用元：
https://doi.org/10.2165/00002512-199710010-00005

データ提供：米国国立医学図書館（NLM）

The Androgen Receptor: A Key Player in Prostate Cancer

Prostate cancer, a significant health concern for men, is driven by the complex interplay of various factors, including androgen receptors. This study investigates the role of androgen receptor gene mutations in prostate cancer, exploring their implications for disease progression and treatment.

Mutations and Prostate Cancer: A Devious Dance

This study unveils the intricate relationship between androgen receptor mutations and prostate cancer. The researchers discovered that these mutations are more prevalent in advanced stages of the disease, particularly in bone metastases. This finding suggests that androgen receptor mutations may play a role in the development of more aggressive forms of prostate cancer and the resistance to conventional therapies.

Prostate Cancer: Understanding the Enemy

Prostate cancer is a complex disease with varying degrees of aggressiveness. Understanding the role of androgen receptor mutations is crucial for developing targeted therapies that can effectively combat the disease and improve patient outcomes. Early detection and prompt medical attention are essential for managing prostate cancer and maximizing treatment success.

Dr.Camel's Conclusion

This study, like a camel carefully traversing a desert landscape, reveals the complex role of androgen receptor mutations in prostate cancer. The findings highlight the importance of understanding these mutations in developing personalized treatments and effectively combating this challenging disease.
Date :
  1. Date Completed 1997-05-08
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

9111707

DOI: Digital Object Identifier

10.2165/00002512-199710010-00005

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Languages

English

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