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Diagnostic phase antibody response to the human papillomavirus type 16 E2 protein is associated with successful treatment of genital HPV lesions with systemic interferon alpha-2b.

Author: HibmaM, LehtinenM, NieminenP, PaavonenJ, StellatoG, ViljaP

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Detectable diagnostic phase levels of serum antibodies to HPV16 ORF E2 derived peptide predicted a 10-fold difference in the risk of recurrence of HPV infection following adjuvant interferon alpha-2b therapy compared with placebo. This trend was statistically significant in the whole study population and in patients with high viral load.
Paper Details　
Original Abstract of the Article :
BACKGROUND AND OBJECTIVE: Systemic interferon alpha-2b treatment reduces relapses of genital human papillomavirus (HPV) lesions in some but not all females. The aim of the present study was to investigate possible predictive pretreatment factors for the outcome of therapy. MATERIAL AND METHODS: HPV...See full text at original site
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引用元：
https://doi.org/10.1016/s0928-0197(96)00267-x

データ提供：米国国立医学図書館（NLM）

Predicting Treatment Success: A Desert Oasis of Hope for HPV Infections

Genital human papillomavirus (HPV) infections are a common concern, and finding effective treatments is essential. This study investigates the role of diagnostic phase antibody responses to HPV16 E2 protein in predicting the success of systemic interferon alpha-2b treatment for HPV lesions. The authors discovered a significant correlation between detectable antibody levels and improved treatment outcomes.

Predictive Power of Antibody Responses: Navigating the Desert of HPV Treatment

This research sheds light on a valuable tool in the fight against HPV infections. The study's findings suggest that diagnostic phase antibody levels to HPV16 E2 protein can predict the effectiveness of interferon alpha-2b treatment. This information can help healthcare providers tailor treatment approaches and improve patient outcomes.

Hope in the Desert: Personalized Treatment Strategies for HPV Infections

The ability to predict treatment success based on antibody levels is a beacon of hope in the desert of HPV infections. This research offers the potential for personalized treatment strategies, allowing healthcare providers to select the most effective treatment options for individual patients. This approach could significantly improve patient outcomes and reduce the burden of HPV infections.

Dr.Camel's Conclusion

This study demonstrates the importance of understanding the nuances of immune responses in treating HPV infections. The authors' discovery of the predictive value of diagnostic phase antibody levels offers a potential roadmap for developing personalized treatment strategies. This research represents a significant step forward in the fight against HPV, offering hope for a future where these infections can be effectively managed.

Date :
  1. Date Completed 1997-06-26
  2. Date Revised 2019-11-02
Further Info :

Pubmed ID

9126686

DOI: Digital Object Identifier

10.1016/s0928-0197(96)00267-x

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Languages

English

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