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Antimicrobial characteristics of quinupristin/dalfopristin (Synercid at 30:70 ratio) compared to alternative ratios for in vitro testing.

Author: BarrettM S, JamjianC, JonesR N

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Quinupristin/dalfopristin, a new streptogramin combination, was found to be effective against a wide range of Gram-positive bacteria, including penicillin-resistant streptococci and glycopeptide-resistant Enterococcus faecium.
Paper Details　
Original Abstract of the Article :
Quinupristin/dalfopristin is a new streptogramin combination that occurs at a natural ratio and formulation of 30:70. Rapid metabolism of the dalfopristin component to RP 12536 in vivo puts in question the validity of in vitro test of spectrum with the parent combination. In studies of quinupristin ...See full text at original site
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引用元：
https://doi.org/10.1016/s0732-8893(97)00031-x

データ提供：米国国立医学図書館（NLM）

Fighting Gram-Positive Infections: Finding the Right Weapon in the Arsenal

Gram-positive infections are like a desert sandstorm, a formidable enemy threatening to overwhelm the body. This research explores the effectiveness of quinupristin/dalfopristin, a streptogramin antibiotic, in treating these infections. It’s like finding a new weapon in the arsenal, potentially capable of combating this powerful foe. The researchers investigated the antimicrobial characteristics of the drug, examining its potency and spectrum of activity against various Gram-positive bacteria.

A Versatile Weapon

The researchers found that quinupristin/dalfopristin exhibited bactericidal activity against a wide range of Gram-positive bacteria, showing its versatility in combating these infections. It’s like discovering a new type of arrow, capable of piercing the armor of the enemy and inflicting damage. The drug also proved effective against strains that were resistant to other antibiotics, like uncovering a hidden wellspring in the desert, offering a vital resource in a time of scarcity.

Defending Against Infections

This research highlights the potential of quinupristin/dalfopristin as a valuable tool in the fight against Gram-positive infections. It’s like finding a new weapon in the arsenal of antibiotics, offering a promising defense against these formidable foes. Further research is needed to fully understand the drug's efficacy in clinical settings and its potential impact on the growing threat of antibiotic resistance.

Dr.Camel's Conclusion

This research sheds light on the potential of quinupristin/dalfopristin in combating Gram-positive infections. It’s like finding a hidden oasis in the vast desert of antibiotic resistance, offering a source of hope and a potential path to recovery. Further research will be crucial to fully understand the drug’s strengths and limitations, ensuring its safe and effective use.

Date :
  1. Date Completed 1997-07-09
  2. Date Revised 2019-09-05
Further Info :

Pubmed ID

9154409

DOI: Digital Object Identifier

10.1016/s0732-8893(97)00031-x

SNS
PICO Info
in preparation
Languages

English

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