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Effect of angiotensin-converting enzyme inhibitor therapy in mitral regurgitation with normal left ventricular function.
Author: BeauvaisD, BlaisM J, DaoustC, HonosG N, LisbonaA, MarcotteF, McCansJ L, WallingA D
Original Abstract of the Article :
Mitral regurgitation (MR) is a common, frequently asymptomatic valvulopathy that can ultimately lead to left ventricular failure. With the objective of forestalling MR progression, a prospective, placebo controlled, double-blind study was conducted. It measured the effectiveness of lisinopril, an an...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/9179087
データ提供:米国国立医学図書館(NLM)
Angiotensin-Converting Enzyme (ACE) Inhibitors: A Potential Boon for Mitral Regurgitation?
This study investigates the potential benefits of ACE inhibitors, like lisinopril, in managing mitral regurgitation (MR), a condition where the heart valve between the left atrium and left ventricle doesn't close properly, leading to leakage. It's like a leaky faucet in your heart, causing a buildup of pressure and potentially leading to heart failure.
The researchers conducted a controlled study involving 23 patients with moderate MR and normal left ventricular function, comparing the effects of lisinopril to a placebo. They found that after a year of treatment, patients taking lisinopril had a significant decrease in the severity of their MR, while those taking the placebo showed an increase in MR severity.
This research provides encouraging evidence that ACE inhibitors could play a role in managing MR, potentially slowing down its progression. While side effects were observed in some patients, the overall safety profile of lisinopril was favorable.
ACE Inhibitors: A Potential Valve Guardian?
These findings suggest that ACE inhibitors could be a valuable tool for managing MR, potentially delaying its progression. However, further research is needed to fully understand the long-term effects of ACE inhibitors on MR and to identify the ideal patient population for this treatment.
Listen to Your Heart and Your Doctor
If you are diagnosed with MR, it's important to consult with your doctor to discuss the best treatment options for your specific condition. ACE inhibitors could be an effective component of your treatment plan, but it's crucial to work with your healthcare provider to make informed decisions about your health.
Dr. Camel's Conclusion
This study suggests that ACE inhibitors, like a gentle hand on the valve, can help slow the progression of MR. It’s a reminder that even in the face of complex heart conditions, there might be effective treatments available. It is important to remember that each person's journey with their health is unique. Listen to your heart, and talk to your doctor about the best path forward.
Date :
- Date Completed 1997-06-19
- Date Revised 2016-11-24
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