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Pharmacokinetics, toxicity, side effects, receptor affinities and in vitro radiosensitizing effects of the novel metoclopramide formulations, sensamide and neu-sensamide.

Author: AmiriA, AndersenI, OlssonA, PeroR W, SimanaitisM

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Neutral metoclopramide, a new formulation of the antiemetic drug, was found to be more bioavailable and safer than acidic metoclopramide when administered intramuscularly to rats.
Paper Details　
Original Abstract of the Article :
Metoclopramide is a drug which has experienced worldwide use in the clinic for over 30 years as an antiemetic. Recently, it has also been shown to possess radio- and chemosensitizing properties in both animal tumour models and humans at the higher dose of 2 mg/kg. Two new metoclopramide formulations...See full text at original site
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引用元：
https://doi.org/10.1111/j.1600-0773.1997.tb01965.x

データ提供：米国国立医学図書館（NLM）

Metoclopramide: A Versatile Tool for Cancer Treatment

Metoclopramide, a well-known antiemetic, has recently emerged as a potential player in cancer treatment. This study explores the potential of two novel metoclopramide formulations, sensamide and neu-sensamide, as radiosensitizers, enhancing the effectiveness of radiation therapy.

The researchers found that neutral metoclopramide, delivered intramuscularly, exhibited significantly higher bioavailability and reduced side effects compared to its acidic counterpart. Furthermore, neutral metoclopramide demonstrated similar radiosensitizing potency, suggesting it could be a valuable tool for cancer treatment.

A Promising New Avenue in Cancer Treatment

This study is like a hidden oasis, offering a promising new avenue in cancer treatment. It highlights the potential of neutral metoclopramide as a safe and effective radiosensitizer, potentially enhancing the effectiveness of radiation therapy and improving patient outcomes.

Navigating the Desert of Cancer Treatment

Cancer treatment is a challenging journey, often fraught with difficult side effects and uncertainties. This study offers hope for improved strategies, potentially minimizing side effects and enhancing the effectiveness of existing treatments. The research underscores the importance of continuous exploration and innovation in the field of cancer therapy, seeking more effective and less toxic approaches.

Dr. Camel's Conclusion

This study reveals the promising potential of neutral metoclopramide as a safe and effective radiosensitizer. Its enhanced bioavailability and reduced side effects, coupled with its similar radiosensitizing potency, make it a valuable tool for cancer treatment. This research underscores the importance of exploring new and innovative approaches to cancer therapy, offering hope for improved outcomes and a brighter future for patients navigating this challenging terrain.
Date :
  1. Date Completed 1997-07-18
  2. Date Revised 2019-09-05
Further Info :

Pubmed ID

9181602

DOI: Digital Object Identifier

10.1111/j.1600-0773.1997.tb01965.x

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SNS
PICO Info
in preparation
Languages

English

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