Tumor blood flow and the cytotoxic effects of estramustine and its constituents in a rat glioma model.

Author: BergenheimA T, HenrikssonR, JohanssonM, KoskinenL O, VallboC, WidmarkA

Paper Details 
Original Abstract of the Article :
Estramustine (EaM) is a conjugate of nor-nitrogen mustard (NNM) and 17 beta-estradiol (E2) that has cytotoxic and radiosensitizing effects on experimental malignant glioma. Its mechanism of action is only partly understood. To further investigate the mechanism in vivo, the effects on tumor blood flo...See full text at original site
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引用元:
https://doi.org/10.1097/00006123-199707000-00038

データ提供:米国国立医学図書館(NLM)

Estramustine: A Targeted Approach to Glioma Treatment

Glioma, a type of brain tumor, can be a formidable opponent, like a formidable sand dune challenging a desert traveler. This study investigates the cytotoxic effects of estramustine, a drug that targets glioma cells, focusing on its potential to disrupt tumor blood flow. The researchers used a rat glioma model to study the effects of estramustine and its constituent components, investigating their ability to reduce tumor growth and blood supply. Their findings suggest that estramustine, particularly its nitrogen mustard component, can effectively reduce tumor blood flow, highlighting its potential as a promising treatment for glioma.

Estramustine: A Potential Weapon Against Glioma

The study suggests that estramustine, particularly its nitrogen mustard component, can effectively disrupt tumor blood flow, potentially leading to improved outcomes for glioma patients. This research offers promising insights into the potential of estramustine as a targeted therapy for glioma, a disease that often poses significant challenges to treatment.

Targeting Tumor Blood Flow: A New Frontier in Glioma Treatment

This study explores a novel approach to glioma treatment, focusing on disrupting tumor blood flow. The researchers demonstrate the potential of estramustine, particularly its nitrogen mustard component, to reduce tumor blood supply. This targeted approach could offer a valuable new weapon in the fight against glioma, potentially leading to more effective treatment strategies and improved outcomes for patients.

Dr.Camel's Conclusion

This study, like a desert traveler discovering a hidden spring, sheds light on a potential new strategy for treating glioma. By targeting tumor blood flow, estramustine could offer a more effective and targeted approach to treatment. This research is a testament to the ongoing quest for better therapies for brain tumors, a journey towards a brighter and more hopeful future for patients battling this challenging condition.

Date :
  1. Date Completed 1997-08-19
  2. Date Revised 2019-05-12
Further Info :

Pubmed ID

9218312

DOI: Digital Object Identifier

10.1097/00006123-199707000-00038

Related Literature

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PICO Info
in preparation
Languages

English

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