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Evaluation of a UDP-glucose-4-epimeraseless mutant of Salmonella typhi as a liver oral vaccine.
Author: DuPontH L, GilmanR H, HornickR B, LevineM M, LibonatiJ P, SnyderM J, WoodardW E
Original Abstract of the Article :
A mutant (Ty21a) of Salmonella typhi, which lacks the enzyme uridine 5'-diphosphate-glucose-4-epimerase, was evaluated in volunteers for use as a live attenuated oral typhoid vaccine. Five to eight doses of vaccine (containing 3-10(10) viable organisms per dose) were given to 155 men without signifi...See full text at original site
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引用元:
https://doi.org/10.1093/infdis/136.6.717
データ提供:米国国立医学図書館(NLM)
UDP-Glucose-4-Epimeraseless Mutant of Salmonella Typhi: A Promising Oral Vaccine
This study evaluated the safety and efficacy of a UDP-glucose-4-epimeraseless mutant of Salmonella typhi, strain Ty21a, as a live attenuated oral typhoid vaccine. The researchers conducted a clinical trial involving volunteers to assess the vaccine's safety, immunogenicity, and protective efficacy against typhoid fever.Ty21a Demonstrates Potential as a Safe and Effective Oral Typhoid Vaccine
The study found that Ty21a was well-tolerated by volunteers, with minimal side effects. The vaccine strain was excreted in the stool at low rates, and revertants were not detected. Volunteers who received the vaccine strain grown in galactose showed significant protection against typhoid fever and reduced stool carriage of S. typhi upon challenge with virulent S. typhi.A New Hope for Typhoid Fever Prevention
This research offers a promising new approach to typhoid fever prevention through the development of a safe and effective oral vaccine. The findings suggest that Ty21a has the potential to significantly reduce the burden of typhoid fever, particularly in regions where this disease is endemic.Dr. Camel's Conclusion
This study explores the potential of a UDP-glucose-4-epimeraseless mutant of Salmonella typhi, strain Ty21a, as a live attenuated oral typhoid vaccine. The research demonstrates the safety and efficacy of this vaccine strain, offering hope for a new generation of typhoid vaccines.Date :
- Date Completed 1978-01-27
- Date Revised 2019-05-09
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