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Mu opioid agonists potentiate amphetamine- and cocaine-induced rotational behavior in the rat.

Author: HoltzmanS G, KimmelH L

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

This study investigated the interaction between opioids and dopaminergic function in rats with unilateral 6-hydroxydopamine-induced lesions of the nigrostriatal pathway. Mu opioid agonists potentiated stimulant-induced rotational behavior. Naltrexone, an opioid antagonist, blocked the potentiating effects of morphine but also increased amphetamine-induced rotational behavior.
Paper Details　
Original Abstract of the Article :
Opioids modulate brain dopaminergic function in various experimental paradigms. This study used the rotational model of behavior in rats with unilateral 6-hydroxydopamine-induced lesions of the nigrostriatal pathway to investigate this interaction. Doses of two presynaptically acting dopaminergic dr...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/9262337

データ提供：米国国立医学図書館（NLM）

Opioids and Stimulants: A Potent Combination?

This research ventures into the complex and often misunderstood world of drug interactions, a topic as intricate and unpredictable as the shifting sands of a desert storm. The study focuses on the interaction between opioid agonists and stimulants, specifically in the context of rotational behavior in rats with brain lesions.

The Intricate Dance of Opioids and Stimulants

The study demonstrates that opioid agonists, such as morphine, can potentiate the rotational behavior induced by stimulants like amphetamine and cocaine. This means that the combination of these drugs can have a more pronounced effect than either drug alone.

Navigating the Desert of Drug Interactions

This research highlights the importance of understanding drug interactions, especially when dealing with powerful medications like opioids and stimulants. The findings underscore the need for careful monitoring and consideration of potential risks and benefits when prescribing these medications.

Dr.Camel's Conclusion

This study reminds us that the desert of drug interactions is full of hidden dangers and unexpected consequences. We must proceed with caution and carefully consider the potential impact of combining different medications.

Date :
  1. Date Completed 1997-09-11
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

9262337

DOI: Digital Object Identifier

9262337

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English

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