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Effects of mesalamine on the hsp72 stress response in rat IEC-18 intestinal epithelial cells.

Author: BurressG C, ChangE B, JurivichD A, MuschM W, WelkJ

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

This study investigated the potential of mesalamine to increase intestinal epithelial hsp72 expression, as a mechanism of cell protection.
Paper Details　
Original Abstract of the Article :
Mesalamine has many effects and is commonly used for the treatment of inflammatory bowel diseases. Because sodium salicylate, a related compound, modulates the heat shock protein (hsp72) response in nonepithelial cells, the possibility that mesalamine confers cell protection by increasing intestinal...See full text at original site
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引用元：
https://doi.org/10.1053/gast.1997.v113.pm9352849

データ提供：米国国立医学図書館（NLM）

Mesalamine: A Potential Protector of Intestinal Cells

Inflammatory bowel diseases (IBDs) are chronic conditions that affect the digestive tract, like a desert storm that can wreak havoc on a fragile ecosystem. This study explores the potential of mesalamine, a drug commonly used to treat IBDs, to protect intestinal epithelial cells from damage.

Mesalamine's Protective Mechanism

The researchers are investigating if mesalamine can increase the expression of heat shock protein 72 (hsp72), a protein that plays a protective role in cells. It's like a desert plant that adapts to harsh conditions, developing mechanisms to survive and thrive. The study aims to understand how mesalamine might work at a cellular level.

Implications for IBD Treatment

If mesalamine is found to protect intestinal cells by boosting hsp72 expression, this could have significant implications for IBD treatment. This could lead to new strategies for managing the disease and improving patient outcomes.

Dr. Camel's Conclusion

This study is a reminder that the quest for better treatments for IBDs continues. By exploring the cellular mechanisms of mesalamine, researchers are gaining a deeper understanding of how this drug might work and its potential to protect intestinal cells.

Date :
  1. Date Completed 1997-11-13
  2. Date Revised 2019-07-07
Further Info :

Pubmed ID

9352849

DOI: Digital Object Identifier

10.1053/gast.1997.v113.pm9352849

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・Effects of mesalamine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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