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Selegiline is ineffective in a collaborative double-blind, placebo-controlled trial for treatment of amyotrophic lateral sclerosis.
Author: AppelS H, AppelV, DiamondB, LaiE C, LangeD J, MurphyP L, YoungerD S
Original Abstract of the Article :
BACKGROUND: The cause of amyotrophic lateral sclerosis (ALS) is not known, and there is no effective treatment. Cell death may be caused by oxidative damage. Selegiline hydrochloride (Eldepryl) is a monoamine oxidase-B inhibitor with antioxidant properties. OBJECTIVE: To determine if selegiline aff...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1001/archneur.55.1.93
データ提供:米国国立医学図書館(NLM)
Selegiline for ALS: A Mirage in the Desert of Treatment
The quest for effective treatments for amyotrophic lateral sclerosis (ALS), a devastating neurodegenerative disease, is a long and arduous journey, much like a camel traversing a vast and unforgiving desert. This study investigated the potential benefits of selegiline, a medication known for its antioxidant properties, in treating ALS. The researchers conducted a double-blind, placebo-controlled trial, which is a rigorous study design, to determine if selegiline could slow the progression of the disease.
Selegiline and ALS: A Disappointing Outcome in the Desert
The study found that selegiline had no significant effect on the rate of clinical progression in ALS patients. This disappointing result is like discovering a mirage in the desert – it offers hope that quickly fades away. The authors concluded that selegiline, despite its potential as an antioxidant, did not demonstrate effectiveness in treating ALS.
Navigating the Desert of ALS: Seeking Hope and Support
The search for effective treatments for ALS continues. This study, while disappointing, highlights the need for ongoing research and development of new therapeutic strategies. Patients and their families must rely on support from healthcare professionals and support groups. It's like finding an oasis in the desert, providing a place of respite and understanding.
Dr.Camel's Conclusion
The desert of ALS research is a challenging landscape, full of hope and disappointment. While this study was not successful, the quest for effective treatments must continue. We must keep searching for new oases of hope in this vast and unforgiving desert.
Date :
- Date Completed 1998-02-06
- Date Revised 2019-07-17
Further Info :
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