Selegiline is ineffective in a collaborative double-blind, placebo-controlled trial for treatment of amyotrophic lateral sclerosis.

Author: AppelS H, AppelV, DiamondB, LaiE C, LangeD J, MurphyP L, YoungerD S

Paper Details 
Original Abstract of the Article :
BACKGROUND: The cause of amyotrophic lateral sclerosis (ALS) is not known, and there is no effective treatment. Cell death may be caused by oxidative damage. Selegiline hydrochloride (Eldepryl) is a monoamine oxidase-B inhibitor with antioxidant properties. OBJECTIVE: To determine if selegiline aff...See full text at original site
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引用元:
https://doi.org/10.1001/archneur.55.1.93

データ提供:米国国立医学図書館(NLM)

Selegiline for ALS: A Mirage in the Desert of Treatment

The quest for effective treatments for amyotrophic lateral sclerosis (ALS), a devastating neurodegenerative disease, is a long and arduous journey, much like a camel traversing a vast and unforgiving desert. This study investigated the potential benefits of selegiline, a medication known for its antioxidant properties, in treating ALS. The researchers conducted a double-blind, placebo-controlled trial, which is a rigorous study design, to determine if selegiline could slow the progression of the disease.

Selegiline and ALS: A Disappointing Outcome in the Desert

The study found that selegiline had no significant effect on the rate of clinical progression in ALS patients. This disappointing result is like discovering a mirage in the desert – it offers hope that quickly fades away. The authors concluded that selegiline, despite its potential as an antioxidant, did not demonstrate effectiveness in treating ALS.

Navigating the Desert of ALS: Seeking Hope and Support

The search for effective treatments for ALS continues. This study, while disappointing, highlights the need for ongoing research and development of new therapeutic strategies. Patients and their families must rely on support from healthcare professionals and support groups. It's like finding an oasis in the desert, providing a place of respite and understanding.

Dr.Camel's Conclusion

The desert of ALS research is a challenging landscape, full of hope and disappointment. While this study was not successful, the quest for effective treatments must continue. We must keep searching for new oases of hope in this vast and unforgiving desert.

Date :
  1. Date Completed 1998-02-06
  2. Date Revised 2019-07-17
Further Info :

Pubmed ID

9443715

DOI: Digital Object Identifier

10.1001/archneur.55.1.93

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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