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A systematic review of five systemic treatments for severe psoriasis.

Author: BosJ D, BossuytP M, SpulsP I, WitkampL

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

This study analyzed 129 studies of 13,677 patients with severe psoriasis to assess the effectiveness of five treatments: UVB, PUVA (photochemotherapy), methotrexate (MTX), retinoids (RET), and cyclosporine A (CYA). PUVA had the highest success rates, achieving complete clearance in 70% of patients and good response in 83%. UVB and cyclosporine A followed with similar, but slightly lower, success rates. Retinoids were associated with the highest rate of side effects, while phototherapy (UVB and PUVA) had the lowest. The study highlights the need for further research comparing different oral treatments to establish the best options for treating severe psoriasis.
Paper Details　
Original Abstract of the Article :
We systematically reviewed the evidence concerning the ability of five systemic treatments to induce remission in patients with severe psoriasis: ultraviolet B (UVB), photochemotherapy (PUVA), methotrexate (MTX), retinoids (RET) and cyclosporin A (CYA). An elaborate literature search was performed, ...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/9470912

データ提供：米国国立医学図書館（NLM）

A Comprehensive Review of Psoriasis Treatments

Psoriasis, a chronic skin condition characterized by scaly patches, has been a focus of research for many years. This systematic review synthesizes the evidence concerning the efficacy of five systemic treatments for severe psoriasis: ultraviolet B (UVB), photochemotherapy (PUVA), methotrexate (MTX), retinoids (RET), and cyclosporin A (CYA). The authors conducted an elaborate literature search, assessed the validity of studies, and analyzed the data to compare the effectiveness of these treatment approaches in achieving remission and reducing psoriasis symptoms.

Navigating the Diverse Terrain of Psoriasis Treatments

This review offers a comprehensive and insightful overview of the various treatment options for severe psoriasis. The study highlights the relative effectiveness of different treatments, including PUVA, UVB, and CYA, in achieving remission and reducing psoriasis symptoms. This is like having a detailed map of a vast desert, guiding clinicians in choosing the most appropriate treatment options for their patients.

Finding the Right Path to Clear Skin

The study underscores the importance of choosing the right treatment approach for each patient, as the effectiveness of different treatments can vary widely. This review provides valuable information that can help clinicians make informed decisions about the best course of treatment for their patients. This is a journey through the desert of psoriasis, where finding the right path to clear skin can make a significant difference in the lives of those affected.

Dr.Camel's Conclusion

This systematic review offers a valuable contribution to our understanding of the treatment landscape for psoriasis. The study highlights the different treatment options and their relative effectiveness, providing valuable insights for clinicians and patients alike. This comprehensive review serves as a guide, like a well-worn trail through the desert, leading to a better understanding of the diverse treatment options available for this challenging condition.

Date :
  1. Date Completed 1998-02-23
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

9470912

DOI: Digital Object Identifier

9470912

Related Literature

Article Analysis
・Effective treatment of psoriasis
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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