Increased lithium serum and red blood cell concentrations during ketorolac coadministration.

Author: AugustinB G, AwadE, ColdJ A, JannM W, SimpsonM A, ZumBrunnenT L

Paper Details 
Original Abstract of the Article :
Case reports of a lithium-ketorolac drug interaction have been published, but no formal investigation of this interaction has been conducted. The objective of the study presented here was to determine significant changes in lithium serum and red blood cell (RBC) concentrations after lithium and keto...See full text at original site
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引用元:
https://doi.org/10.1097/00004714-199802000-00006

データ提供:米国国立医学図書館(NLM)

A Drug Interaction to Watch Out For: Lithium and Ketorolac

In the world of pharmacology, drug interactions are like unexpected sandstorms in the desert—they can disrupt the intended course of treatment. This study investigates the potential interaction between lithium and ketorolac, two commonly prescribed medications. The researchers, like explorers venturing into uncharted territory, sought to determine whether coadministration of these drugs could lead to changes in lithium levels.

The results of this study revealed a significant interaction between lithium and ketorolac. The researchers observed a significant increase in both serum and red blood cell lithium concentrations when ketorolac was added to lithium therapy. This interaction could potentially lead to an increased risk of lithium-associated side effects, raising concerns about patient safety.

The Importance of Careful Monitoring

This research highlights the importance of careful monitoring for drug interactions, particularly when coadministering lithium and ketorolac. Just as a camel must navigate the desert with caution, healthcare professionals must be vigilant in assessing the potential risks of combining medications.

Ensuring Patient Safety

This study underscores the importance of patient safety in drug therapy. By understanding the potential interactions between medications, healthcare providers can make informed decisions that minimize the risk of adverse effects and optimize treatment outcomes for their patients.

Dr. Camel's Conclusion

This study is like a warning sign in the desert of drug interactions. It reveals the potential dangers of combining lithium and ketorolac, emphasizing the need for careful monitoring and proactive management to ensure patient safety. As a researcher who has seen the complexities of drug interactions, I am reminded of the importance of vigilance and informed decision-making in prescribing medications.

Date :
  1. Date Completed 1998-04-02
  2. Date Revised 2019-09-09
Further Info :

Pubmed ID

9472840

DOI: Digital Object Identifier

10.1097/00004714-199802000-00006

Related Literature

SNS
PICO Info
in preparation
Languages

English

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