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Pharmacokinetic/pharmacodynamic evaluation of systemic effects of flunisolide after inhalation.

Author: BarthJ, DerendorfH, HochhausG, KnöllerJ, KriegM, MeibohmB, MöllmannA, MöllmannH, WagnerM, WeisserH

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Flunisolide, an inhaled glucocorticoid, had a short half-life and systemic effects, with cumulative cortisol suppression increasing with dose.
Paper Details　
Original Abstract of the Article :
The pharmacokinetics and pharmacodynamics of flunisolide were studied in healthy volunteers after inhalation. In the morning on the day the study began, volunteers inhaled 0.5 mg of flunisolide with and without oral administration of charcoal, or 1 mg, 2 mg, and 3 mg of flunisolide with concomitant ...See full text at original site
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引用元：
https://doi.org/10.1002/j.1552-4604.1997.tb04263.x

データ提供：米国国立医学図書館（NLM）

Flunisolide's Systemic Effects: A Journey Through Inhalation

The world of drug delivery is a vast desert, with various pathways to deliver medications to their target sites. This study, published in the field of Pharmacokinetics, focuses on the systemic effects of flunisolide, a glucocorticoid, following inhalation. The researchers explored the pharmacokinetic and pharmacodynamic profiles of flunisolide in healthy volunteers, analyzing its absorption, distribution, metabolism, and excretion. This research delves into the intricate dance between drug administration and its impact on the body.

Flunisolide's Transient Effects: A Shifting Mirage

The study found that flunisolide achieved peak plasma levels rapidly after inhalation, with a short half-life, leading to transient systemic effects. The study also demonstrated a dose-dependent relationship between flunisolide levels and its effects on cortisol suppression, granulocyte, and lymphocyte counts.

Understanding Drug Delivery: A Guide Through the Desert of Pharmacology

This research offers valuable insights into the pharmacokinetics and pharmacodynamics of inhaled glucocorticoids. It provides crucial information for optimizing drug delivery and minimizing potential side effects.

Dr.Camel's Conclusion

This research sheds light on the complex relationship between drug delivery and systemic effects. It highlights the importance of careful dose optimization and understanding the pharmacokinetic profiles of inhaled drugs.

Date :
  1. Date Completed 1998-03-30
  2. Date Revised 2021-09-01
Further Info :

Pubmed ID

9505980

DOI: Digital Object Identifier

10.1002/j.1552-4604.1997.tb04263.x

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Languages

English

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