Paper Details
- Home
- Paper Details
Clonidine potentiates the neuropathic pain-relieving action of MK-801 while preventing its neurotoxic and hyperactivity side effects.
Author: Jevtovic-TodorovicV, NardiA, OlneyJ W, PowellS, WozniakD F
Original Abstract of the Article :
Antagonists of NMDA glutamate receptors have been shown to alleviate neuropathic pain in rats and humans. However, NMDA antagonists can cause significant side effects ranging from behavioral disturbances to injury of neurons in the posterior cingulate/retrosplenial (PC/RS) cortex. We have found that...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元：
https://doi.org/10.1016/s0006-8993(97)01247-x
データ提供：米国国立医学図書館（NLM）
Clonidine and MK-801: A Synergistic Approach to Relieving Neuropathic Pain
Neuropathic pain, a debilitating condition characterized by [chronic pain], poses a significant challenge in [pain management]. This research explores the potential of combining [MK-801], an [NMDA glutamate receptor antagonist], with [clonidine], an [alpha-2 adrenergic agonist], to alleviate neuropathic pain in rats. The study found that [MK-801 effectively relieved neuropathic pain] in rats, but it also caused [neurotoxic and hyperactivity side effects]. However, the study revealed that [clonidine prevented the neurotoxic and hyperactivity side effects of MK-801]. The researchers observed that [combining clonidine with MK-801 provided specific, complete, and long-lasting relief from neuropathic pain] while [preventing the side effects of MK-801].
Clonidine and MK-801: A Synergistic Approach to Pain Management
The study's findings suggest that [combining clonidine with MK-801] could be an effective approach to managing neuropathic pain, offering a potential solution to the challenges associated with using MK-801 alone. The study's results highlight the potential of combining different medications to achieve synergistic effects, improving treatment outcomes while minimizing side effects.
Understanding the Complexities of Neuropathic Pain
Neuropathic pain is a complex condition that can be challenging to manage. This research explores the potential of combining clonidine with MK-801 to alleviate neuropathic pain in rats. Remember, just as the desert holds hidden oases, the field of pain management is constantly seeking new and effective approaches to improve patient quality of life.
Dr.Camel's Conclusion
The study's findings suggest that combining clonidine with MK-801 could be an effective approach to managing neuropathic pain, offering a potential solution to the challenges associated with using MK-801 alone. This research underscores the importance of exploring synergistic drug combinations to improve treatment outcomes while minimizing side effects. Remember, just as a desert traveler might encounter a hidden spring, the field of pain management is constantly searching for new and effective solutions to alleviate suffering.
Date :
- Date Completed 1998-04-29
- Date Revised 2019-06-14
Further Info :
Related Literature
English
This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.