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Azathioprine: state of the art in inflammatory bowel disease.

Author: SandbornW J

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

6-mercaptopurine (6MP) and azathioprine (AZA) are effective and safe for selected patients with inflammatory bowel disease (IBD), with controlled trials supporting their use in inflammatory and fistulizing Crohn's disease, steroid sparing, and remission maintenance.
Paper Details　
Original Abstract of the Article :
INTRODUCTION: The use of 6-mercaptopurine (6MP) and its prodrug azathioprine (AZA) for inflammatory bowel disease (IBD) has increased in recent years. The pharmacology, patient response in controlled trials, new formulations and routes of administration and safety for these agents are reviewed. PHA...See full text at original site
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引用元：
https://doi.org/10.1080/003655298750027290

データ提供：米国国立医学図書館（NLM）

Azathioprine: A Powerful Tool in the Management of Inflammatory Bowel Disease

This review explores the use of azathioprine (AZA) in the treatment of inflammatory bowel disease (IBD). It's like a journey through a medical library, seeking to understand the role of this powerful medication in managing this chronic condition. The authors delve into the pharmacology, clinical response, and safety of AZA in IBD patients.

Azathioprine's Effectiveness in IBD: A Comprehensive Overview

This review provides a comprehensive overview of AZA's effectiveness in various IBD indications, including inflammatory Crohn's disease, fistulizing Crohn's disease, and ulcerative colitis. It's like a detailed map of the medical landscape, guiding clinicians towards informed decisions regarding AZA use in IBD management. The review highlights the potential benefits and limitations of AZA therapy, providing valuable information for clinicians and patients.

Navigating the Landscape of IBD Treatment: Understanding the Risks and Benefits of Azathioprine

This review emphasizes the importance of understanding the potential risks and benefits of AZA therapy in IBD. It's like navigating a complex desert landscape, being aware of both the challenges and opportunities. The authors provide information on potential side effects, such as pancreatitis, leukopenia, and infection, as well as the potential for improved disease control and reduced steroid dependence. This comprehensive overview empowers clinicians to make informed decisions about AZA therapy, considering the individual needs and circumstances of their patients.

Dr.Camel's Conclusion

This review offers a valuable resource for understanding the role of AZA in IBD management. It's a testament to the ongoing efforts in medical research to find effective and safe treatment options for chronic diseases. By being informed about the potential benefits and risks of AZA therapy, clinicians can provide optimal care and improve the lives of individuals with IBD.

Date :
  1. Date Completed 1998-05-14
  2. Date Revised 2019-09-21
Further Info :

Pubmed ID

9515759

DOI: Digital Object Identifier

10.1080/003655298750027290

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English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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