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Enzyme-inducing effects of bicalutamide in mouse, rat and dog.

Author: ButtersC J, DoughtyS E, EdwardsT L, HillS J, McKillopD, SimonsP J

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Bicalutamide, a non-steroidal antiandrogen, induced cytochrome P450 (P450) and aldrin epoxidase activity in dogs, mice, and rats. The induction of specific P450 isoforms varied across species. In rats, bicalutamide primarily induced CYP3A1, while in mice, CYP2B isoforms were more significantly increased. While bicalutamide may induce enzyme activity in rodents, it does not do so at clinically relevant doses in humans.
Paper Details　
Original Abstract of the Article :
1. Bicalutamide, a non-steroidal antiandrogen, produced dose-related increases in total cytochrome P450 (P450) and aldrin epoxidase, but had no effect on ethoxyresorufin O-deethylase, when administered for 10 weeks at 0, 25, 75 and 150 mg/kg/day to the male dog. 2. In the male and female mouse, bica...See full text at original site
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引用元：
https://doi.org/10.1080/004982598239399

データ提供：米国国立医学図書館（NLM）

Bicalutamide: A Non-Steroidal Antiandrogen with Enzyme-Inducing Effects

This research investigates the enzyme-inducing effects of bicalutamide, a non-steroidal antiandrogen used in the treatment of prostate cancer. The study examines the effects of bicalutamide on various cytochrome P450 (CYP) enzymes in mice, rats, and dogs. The authors find that bicalutamide induces CYP enzymes in mice and rats, but not in dogs. The study also investigates the effects of bicalutamide on its own metabolism, concluding that it induces its own metabolism in rats.

Understanding the Enzyme-Inducing Effects of Bicalutamide

The study highlights the species-specific effects of bicalutamide on CYP enzymes. The authors find that bicalutamide induces CYP enzymes in mice and rats, but not in dogs. This information is essential for understanding the potential interactions of bicalutamide with other drugs and for tailoring treatment regimens for individual patients.

The Importance of Drug Interactions: A Desert of Complexity

This research underscores the importance of considering drug interactions when prescribing medications. Like the ever-changing landscape of a desert, the human body is a complex system where interactions between drugs can significantly influence their efficacy and safety. The study’s findings highlight the importance of careful monitoring and adjusting treatment plans to minimize potential interactions and ensure patient safety.

Dr.Camel's Conclusion

This research provides valuable insights into the enzyme-inducing effects of bicalutamide, emphasizing the importance of understanding species-specific differences and the potential for drug interactions. It’s a reminder that navigating the desert of drug interactions requires careful attention and a thorough understanding of the medications being prescribed.

Date :
  1. Date Completed 1998-08-20
  2. Date Revised 2019-12-27
Further Info :

Pubmed ID

9622849

DOI: Digital Object Identifier

10.1080/004982598239399

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・Effects of bicalutamide
SNS
PICO Info
in preparation
Languages

English

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