Effects of IFN-beta on human cerebral blood flow distribution.

Author: BeverC T, CameronE, MackowiakP A, NessaiverM S, SiegelE, WassermanS S

Paper Details 
Original Abstract of the Article :
The effect of interferon-beta1b (IFN-beta) on human cerebral blood flow distribution was examined in five multiple sclerosis patients using functional brain single-photon emission tomography (SPECT). Of nine regions of interest studied, only the basal ganglia exhibited a significant change (increase...See full text at original site
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引用元:
https://doi.org/10.1089/jir.1998.18.393

データ提供:米国国立医学図書館(NLM)

Interferon-beta and Cerebral Blood Flow: Exploring the Effects on the Brain

This study delves into the intricate workings of interferon-beta1b (IFN-beta), a medication commonly used to treat multiple sclerosis, and its impact on the brain. The researchers, like explorers venturing into uncharted territory, use functional brain single-photon emission tomography (SPECT) to examine the effects of IFN-beta on cerebral blood flow. Their investigation reveals a fascinating finding: IFN-beta seems to increase blood flow specifically to the basal ganglia, a region of the brain involved in movement control and other important functions.

Potential Implications for Side Effects

The researchers cautiously note that the observed increase in blood flow to the basal ganglia correlates with changes in mean arterial pressure. This finding, like a whisper in the wind, hints at potential implications for IFN-beta-induced central nervous system side effects. Further research is needed to fully understand the significance of these observations and their impact on patient well-being.

Dr. Camel's Conclusion

This study provides a valuable glimpse into the complex interaction between interferon-beta and the brain. While more research is needed to understand the full implications of these findings, they highlight the importance of carefully monitoring patients for potential side effects and the need for further investigation to enhance the safety and efficacy of IFN-beta treatment.

Date :
  1. Date Completed 1998-10-16
  2. Date Revised 2016-11-24
Further Info :

Pubmed ID

9660246

DOI: Digital Object Identifier

10.1089/jir.1998.18.393

Related Literature

SNS
PICO Info
in preparation
Languages

English

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