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Effects of fatty acid sucrose esters on ceftibuten transport by rat intestinal brush-border membrane vesicles.

Author: KawashimaS, KogaK, MurakamiM

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

The study investigated the effects of fatty acid sucrose esters on drug transport in rat intestinal brush-border membrane vesicles. It found that mono-acyl sucrose esters inhibited drug transport, while polyacyl ester mixtures did not. This suggests that the effects of fatty acid sucrose esters on drug transport are related to their dispersion properties.
Paper Details　
Original Abstract of the Article :
The effects of fatty acid sucrose esters on membrane lipid dynamics and ceftibuten transport by rat intestinal brush-border membrane vesicles (BBMV) were examined to clarify the differences in the action of mono- and poly-acyl sucrose esters on the drug transport. Fatty acid sucrose mono-acyl ester ...See full text at original site
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難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

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引用元：
https://doi.org/10.1248/bpb.21.747

データ提供：米国国立医学図書館（NLM）

Fatty Acid Sucrose Esters: Exploring Drug Transport Mechanisms

Drug delivery is a complex process, involving the movement of medications through the body. This research, like a scientist delving into the intricate world of drug transport, examines the effects of fatty acid sucrose esters on ceftibuten transport by rat intestinal brush-border membrane vesicles (BBMV). The researchers investigated the impact of these pharmaceutical adjuvants on the movement of ceftibuten, an antibiotic, across the intestinal membrane.

Understanding Drug Transport: A Journey Through Membranes

The study's findings reveal that fatty acid sucrose esters can influence drug transport mechanisms. The researchers observed that different types of esters had varying effects on ceftibuten transport, highlighting the importance of understanding the specific properties of pharmaceutical adjuvants. This knowledge, like a map guiding us through the complex maze of drug delivery, is crucial for developing more effective and targeted drug therapies.

Optimizing Drug Delivery: A Path to Improved Treatment

This research provides valuable insights into the influence of pharmaceutical adjuvants on drug transport. The researchers' findings, like a compass guiding us through the desert of drug delivery, highlight the importance of carefully selecting adjuvants to optimize drug delivery and enhance treatment efficacy.

Dr. Camel's Conclusion

This research delves into the complex world of drug transport, exploring the impact of fatty acid sucrose esters on ceftibuten transport. The researchers' findings emphasize the importance of understanding the specific properties of pharmaceutical adjuvants in order to optimize drug delivery and improve treatment outcomes.
Date :
  1. Date Completed 1998-10-22
  2. Date Revised 2019-07-19
Further Info :

Pubmed ID

9703261

DOI: Digital Object Identifier

10.1248/bpb.21.747

Related Literature

Article Analysis
・Effects of ceftibuten
SNS
PICO Info
in preparation
Languages

English

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