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Ecteinascidin-743, a new marine natural product with potent antitumor activity on human ovarian carcinoma xenografts.

Author: D'IncalciM, FairclothG, GiavazziR, HendriksH, JimenoJ, NicolettiM I, PellegrinoA, ValotiG

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Ecteinascidin (ET)-743, a marine natural product, showed antitumor activity against human ovarian carcinoma xenografts. It was highly active against some tumor models, suggesting potential for clinical use.
Paper Details　
Original Abstract of the Article :
The antitumor activity of ecteinascidin (ET)-743, a novel marine natural product, was evaluated against a panel of human ovarian carcinoma xenografts characterized by different malignant behaviors and drug responsiveness in nude mice. These tumor models included three xenografts transplanted s.c. (H...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/9717828

データ提供：米国国立医学図書館（NLM）

Ecteinascidin-743: A Promising New Treatment for Ovarian Cancer

Ovarian cancer, like a desert mirage, can be elusive and challenging to treat. This study, like a scientific expedition venturing into uncharted waters, investigates the potential of ecteinascidin-743, a novel marine natural product, as a therapeutic agent for this devastating disease.

Ecteinascidin-743: A Powerful Weapon Against Ovarian Cancer

Researchers, like skilled navigators charting a course through a treacherous sea, conducted preclinical studies using human ovarian carcinoma xenografts in nude mice. The results, like a ship's compass guiding its course, showed that ecteinascidin-743 exhibited potent antitumor activity, particularly against ovarian cancer cells that were sensitive to cisplatinum.

Hope on the Horizon: Ecteinascidin-743's Potential for Clinical Application

This research, like a lighthouse illuminating the path forward, provides a glimmer of hope for patients battling ovarian cancer. The study's findings suggest that ecteinascidin-743 could be a promising new therapeutic option, offering a potential avenue for treatment. However, further research, like a thorough exploration of a new land, is needed to fully understand its efficacy and optimize its clinical application.

Dr. Camel's Conclusion

This research, like a desert oasis providing much-needed respite, offers hope for patients with ovarian cancer. The study's findings suggest that ecteinascidin-743 could be a valuable addition to the arsenal of available treatments for this challenging disease. However, more research is needed to determine its full potential and ensure its safe and effective use.
Date :
  1. Date Completed 1998-10-22
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

9717828

DOI: Digital Object Identifier

9717828

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English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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