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Hemodynamic, cardiac, and electrolyte effects of low-dose aerosolized terbutaline sulfate in asthmatic patients.

Author: BradenG L, BriaW F, GermainM J, HaferJ G, MulhernJ G

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study aimed to investigate whether beta-adrenergic tolerance to inhaled terbutaline develops during 14 days of maintenance therapy.
Paper Details　
Original Abstract of the Article :
Aerosolized beta2-agonists have been associated with increased morbidity in asthmatics. These drugs cause transient increases in heart rate and decreases in serum potassium levels after these drugs are first utilized. This study is designed to elucidate whether beta-adrenergic tolerance to the hemod...See full text at original site
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引用元：
https://doi.org/10.1378/chest.114.2.380

データ提供：米国国立医学図書館（NLM）

Inhaled Terbutaline: A Desert Oasis for Asthma Treatment

Asthma, a chronic respiratory condition, often requires the use of inhaled beta2-agonists to relieve symptoms. However, concerns about potential adverse effects of these medications, such as transient increases in heart rate and decreases in serum potassium levels, have led to questions about their long-term safety. This study, like a camel carefully navigating the shifting sands of asthma management, sought to determine if tolerance to the hemodynamic, cardiac, and electrolyte effects of inhaled terbutaline develops over time.

Navigating the Sands of Asthma Treatment: Exploring Tolerance

The study found that patients did develop tolerance to the hemodynamic, cardiac, and electrolyte effects of inhaled terbutaline during 14 days of maintenance therapy. This finding is like discovering a refreshing oasis in the desert, where the initial impact of the medication gradually diminishes, allowing for more sustained relief from asthma symptoms. The study's findings provide valuable insights into the long-term use of inhaled beta2-agonists in asthma management.

A Breath of Relief: Understanding Medication Effects

For patients with asthma, it is crucial to understand the potential effects of inhaled beta2-agonists and to discuss any concerns with their healthcare providers. This study helps to clarify the development of tolerance to these medications, providing reassurance for patients who rely on them for symptom management. It's like finding a dependable guide in the desert, who can provide insights and support throughout the journey.

Dr. Camel's Conclusion

This study, like a compass guiding travelers across the vast desert of asthma treatment, offers valuable insights into the long-term use of inhaled terbutaline. The finding that tolerance develops over time is reassuring for patients and clinicians alike, promoting the safe and effective use of this medication. As a researcher, I am impressed by the meticulous approach employed in this study and its potential to improve the lives of individuals with asthma.
Date :
  1. Date Completed 1998-09-15
  2. Date Revised 2019-05-14
Further Info :

Pubmed ID

9726718

DOI: Digital Object Identifier

10.1378/chest.114.2.380

SNS
PICO Info
in preparation
Languages

English

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