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Food restriction-mediated adrenal influences on antigen-induced bronchoconstriction and airway eosinophil influx in the guinea pig.

Author: HayD W, MatthewsJ K, OsbornR R, UnderwoodD C

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Food restriction in guinea pigs resulted in a significant decrease in the severity of bronchoconstriction (60% lower) following antigen exposure. This reduction in bronchoconstriction was associated with an increase in epinephrine and cortisol levels, suggesting a stress response. However, this phenomenon was not observed in conscious guinea pigs, suggesting that the effect may be specific to anesthetized guinea pigs. Treatment with PEG also reduced the severity of bronchoconstriction in both fasted and fed guinea pigs.
Paper Details　
Original Abstract of the Article :
The aim of this study was to measure the effects of food restriction on antigen-induced bronchoconstriction and inflammatory cell influx in guinea pigs and to determine the role of plasma cortisol and catecholamine concentrations. Ovalbumin (OA; 0.3 mg/kg, i.v.) was administered to OA-sensitized, an...See full text at original site
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引用元：
https://doi.org/10.1159/000023990

データ提供：米国国立医学図書館（NLM）

Food Restriction and Bronchoconstriction: The Role of Adrenal Hormones

This research delves into the complex interplay between food restriction, stress hormones, and airway inflammation, focusing on the impact of food restriction on antigen-induced bronchoconstriction and eosinophil influx in guinea pigs. The study investigates the role of plasma cortisol and catecholamines in this process, revealing a complex interplay between physiological stress and airway reactivity.

Exploring the Interplay of Food Restriction and Airway Inflammation

This study explores the intricate relationship between food restriction, stress hormones, and airway inflammation. It's like uncovering the delicate balance of a desert ecosystem – each element plays a role in the overall health of the system. The research suggests that food restriction may influence airway reactivity through the release of stress hormones from the adrenal glands.

Implications for Understanding Asthma and Allergies

The study's findings have important implications for understanding asthma and allergies. It's like deciphering the secrets of a desert sandstorm – understanding the role of stress hormones in airway inflammation can lead to new strategies for managing these conditions. The research highlights the potential for developing new therapeutic approaches that target the adrenal axis and its impact on airway reactivity.

Dr.Camel's Conclusion

This study sheds light on the intricate connections between food restriction, stress hormones, and airway inflammation. It's like navigating a desert landscape – understanding the interplay of these factors is essential for developing effective strategies for managing asthma and allergies.

Date :
  1. Date Completed 1998-10-21
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

9751848

DOI: Digital Object Identifier

10.1159/000023990

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・Effects of epinephrine oral inhalation
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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