Acute effects of the oral administration of midodrine, an alpha-adrenergic agonist, on renal hemodynamics and renal function in cirrhotic patients with ascites.

Author: AngeliP, BortoluzziA, BottaroS, CasigliaE, CraigheroR, De ToniR, FinucciG F, GattaA, PavanL, PiovanD, SticcaA, VolpinR

Paper Details 
Original Abstract of the Article :
The effects of the acute administration of arterial vasoconstrictors on renal plasma flow (RPF) and urinary sodium excretion (UNaV) in cirrhotic patients with ascites with or without hepatorenal syndrome (HRS) are still controversial. As a consequence, vasoconstrictors are not actually used in the t...See full text at original site
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引用元:
https://doi.org/10.1002/hep.510280407

データ提供:米国国立医学図書館(NLM)

Midodrine: A Potential Oasis in the Desert of Liver Disease

Dr. Camel here, your guide through the often challenging landscape of liver disease, a condition that can feel like navigating a desert where resources are scarce.

This study examines the acute effects of midodrine, an alpha-adrenergic agonist, on renal hemodynamics and function in patients with cirrhosis and ascites. Think of this as exploring a new oasis in the desert of liver disease, testing the waters to see if they can offer relief.

A New Source of Hydration in the Desert of Cirrhosis

The study found that midodrine, an oral medication, significantly improved systemic hemodynamics in non-azotemic patients with cirrhosis and ascites. This improvement was associated with better renal perfusion and sodium excretion. The results are like discovering a new spring in the desert, offering a potential lifeline for those struggling with fluid retention.

Health Implications and Practical Applications

This research may have important implications for the treatment of patients with cirrhosis and ascites. It's essential to discuss these new findings with your doctor to determine if midodrine might be an appropriate treatment option for you.

Dr. Camel's Conclusion

This study offers a glimmer of hope in the midst of the challenges posed by liver disease. It's a reminder that even in the most barren deserts of illness, there are often new oases waiting to be discovered.
Date :
  1. Date Completed 1998-11-05
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

9755229

DOI: Digital Object Identifier

10.1002/hep.510280407

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Article Analysis
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PICO Info
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Languages

English

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