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Effects of cefepime, cefixime and ceftibuten on murine gut colonization by Candida albicans.

Author: AnatoliotakisN, BarbounakisE, ChatzinikolaouI, MarakiS, PlatakiM, SamonisG, TselentisY

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the effect of various antibiotics on stool yeast concentration in mice colonized with Candida albicans. While cefepime, cefixime, and ceftibuten showed a slight increase in yeast counts, the increase was not significant. Ceftriaxone, known to increase yeast concentration, served as a positive control. No dissemination of Candida occurred.
Paper Details　
Original Abstract of the Article :
Crl:CD1(ICR) BR mice were fed chow containing Candida albicans or regular chow. Both groups were subsequently given either antibiotics or normal saline. Stool cultures were performed before, at the end of treatment and 1 week after treatment, to determine the effect on the stool yeast concentration....See full text at original site
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引用元：
https://doi.org/10.1159/000007151

データ提供：米国国立医学図書館（NLM）

Cefepime, Cefixime, and Ceftibuten: Effects on Candida albicans Colonization in the Gut

This study investigates the effects of three cephalosporin antibiotics (cefepime, cefixime, and ceftibuten) on the gut colonization of Candida albicans in mice. Candida albicans is a common fungus that can cause infections, particularly in individuals with weakened immune systems. This study examines the potential impact of these antibiotics on the balance of microorganisms in the gut, which is like a delicate desert ecosystem.

Antibiotics and the Gut Microbiome: A Delicate Balance

The study found that the cephalosporin antibiotics did not significantly affect the colonization of Candida albicans in the gut. The researchers conclude that these antibiotics do not appear to promote the growth of Candida albicans in the gut. This is important information for clinicians who are prescribing these antibiotics for patients who may be at risk for Candida albicans infections. It's like carefully navigating a delicate desert ecosystem, ensuring that the balance of organisms is not disrupted by external interventions.

Understanding the Complexities of the Gut Microbiome

This research highlights the importance of understanding the complex interactions between antibiotics and the gut microbiome. The study found that while these cephalosporins did not promote the growth of Candida albicans, other antibiotics, like ceftriaxone, can significantly increase the colonization of this fungus. This suggests that the effects of antibiotics on the gut microbiome can vary depending on the specific antibiotic used. It's like navigating a vast and intricate desert, where the impact of different interventions can be unpredictable and require careful observation and understanding.

Dr. Camel's Conclusion

This research provides valuable insights into the effects of cephalosporin antibiotics on the gut colonization of Candida albicans. It's like exploring a delicate desert ecosystem, where the balance of organisms is crucial for maintaining health. The study highlights the importance of understanding the complex interactions between antibiotics and the gut microbiome to ensure the safety and effectiveness of treatment.
Date :
  1. Date Completed 1998-11-18
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

9755300

DOI: Digital Object Identifier

10.1159/000007151

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・Effects of ceftibuten
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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