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Reduced thiopurine methyltransferase activity and development of side effects of azathioprine treatment in patients with rheumatoid arthritis.

Author: BoerboomsA M, MullerW H, StolkJ N, de AbreuR A, de KoningD G, van BeusekomH J, van de PutteL B

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Patients with rheumatoid arthritis who have inherited lower levels of thiopurine methyltransferase (TPMT) are at higher risk for severe side effects when taking azathioprine. This risk is significant for those with 'intermediate' TPMT activity, suggesting the need for TPMT measurement before treatment initiation.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: To investigate thiopurine enzyme activities for their possible value in predicting the development of azathioprine (AZA)-related toxicity in patients with rheumatoid arthritis (RA). METHODS: Patients with longstanding RA (n = 33) were enrolled in a study of treatment with AZA. Before the...See full text at original site
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引用元：
https://doi.org/10.1002/1529-0131(199810)41:10<1858::AID-ART19>3.0.CO;2-8

データ提供：米国国立医学図書館（NLM）

Thiopurine Methyltransferase: A Key Player in Rheumatoid Arthritis Treatment

The vast landscape of rheumatoid arthritis (RA) research continues to yield new insights. This study explores the role of thiopurine methyltransferase (TPMT) activity in predicting the development of azathioprine (AZA)-related toxicity in patients with RA. It's like navigating a desert, where understanding the terrain is crucial to avoiding potential hazards.

TPMT Activity: A Predictor of Toxicity

The study found a strong correlation between low TPMT activity and the development of severe side effects, particularly gastrointestinal intolerance, in patients receiving AZA treatment. This is a critical discovery, as it highlights the importance of measuring TPMT activity before initiating AZA treatment. This could prevent potential adverse effects and ensure the safe and effective management of RA.

Personalized Medicine in Rheumatoid Arthritis

The study emphasizes the importance of personalized medicine in RA treatment. By tailoring treatment strategies based on individual TPMT activity, clinicians can optimize outcomes and minimize the risk of toxicity. It's like customizing a caravan for a desert journey, ensuring a smooth and safe passage. This approach could revolutionize RA treatment, leading to better outcomes and improved quality of life for patients.

Dr. Camel's Conclusion

This research underscores the crucial role of TPMT activity in predicting AZA-related toxicity in RA patients. It emphasizes the importance of personalized medicine, where treatment strategies are tailored to individual needs. It's a reminder that even in the vast and complex landscape of RA, knowledge and innovation can guide us towards safer and more effective treatment options.

Date :
  1. Date Completed 1998-11-03
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

9778228

DOI: Digital Object Identifier

10.1002/1529-0131(199810)41:10<1858::AID-ART19>3.0.CO;2-8

Related Literature

Article Analysis
・Side Effects of azathioprine
SNS
PICO Info
in preparation
Languages

English

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