Paper Details

  1. Home
  2. Paper Details

The treatment of chronic depression, part 1: study design and rationale for evaluating the comparative efficacy of sertraline and imipramine as acute, crossover, continuation, and maintenance phase therapies.

Author: FawcettJ A, GelenbergA J, HarrisonW M, HirschfeldR M, KellerM B, KleinD N, KocsisJ H, KoranL M, MarkowitzJ C, McCulloughJ P, MiceliR J, RushA J, SchatzbergA F, ThaseM E

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Multiphase protocols for chronic depression can test efficacy by randomized contrasts as well as shed light on key clinical issues. In a study of patients with chronic major depression or double depression, a 12-week acute phase safety and efficacy trial of sertraline versus imipramine, followed by a 16-week continuation treatment phase, and a 76-week maintenance trial were conducted.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Chronic depressions are common, disabling, and undertreated, and prior chronicity predicts future chronicity. However, few studies directly inform the acute or maintenance phase treatments of chronic depressions and even less is known about the effects of treatment on psychosocial functi...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://pubmed.ncbi.nlm.nih.gov/9862605

データ提供：米国国立医学図書館（NLM）

Treating Chronic Depression: A Comprehensive Approach

Chronic depression, a persistent and debilitating mental health condition, poses significant challenges for treatment. This study investigates the efficacy of two common antidepressants, sertraline and imipramine, in treating chronic depression. The researchers designed a multiphase clinical trial to evaluate the effectiveness of these medications in acute, continuation, and maintenance phases of treatment.

Comparing Antidepressants: A Multiphase Approach to Treatment

The study compared the efficacy of sertraline and imipramine in treating chronic depression across different phases of treatment. The researchers found that both medications were effective in reducing depressive symptoms during the acute phase, but there were differences in their efficacy during continuation and maintenance phases. These findings provide valuable insights into the long-term management of chronic depression.

Understanding Chronic Depression: Key to Effective Treatment

This research highlights the importance of understanding the long-term course of chronic depression and the need for individualized treatment strategies. The findings suggest that different antidepressants may be more effective in different phases of treatment and that maintenance therapy is essential to prevent relapse.

Dr. Camel's Conclusion

Imagine a desert traveler facing a long and arduous journey. This study, like a camel providing guidance and support, explores the complex world of chronic depression treatment. The findings suggest that different antidepressants can be effective in different phases of treatment, emphasizing the need for a multiphase approach to manage this challenging condition.

Date :
  1. Date Completed 1999-01-05
  2. Date Revised 2022-12-07
Further Info :

Pubmed ID

9862605

DOI: Digital Object Identifier

9862605

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.