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Antitumor activity of 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl) adenine, a novel deoxyadenosine analog, against human colon tumor xenografts by oral administration.
Author: AkinagaS, KanazawaJ, OkabeM, TakahashiT, TamaokiT
Original Abstract of the Article :
2-Chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl) adenine (Cl-F-araA) is a novel deoxyadenosine analog, which inhibits DNA synthesis by inhibiting DNA polymerase alpha and ribonucleotide reductase. Cl-F-araA shows potent antiproliferative activity against several leukemic cell lines including th...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1007/s002800050889
データ提供:米国国立医学図書館(NLM)
Cl-F-araA: A Novel Deoxyadenosine Analog for Colon Cancer Treatment
Cancer research continues to explore novel therapeutic strategies, including the development of targeted drugs. This study introduces Cl-F-araA, a novel deoxyadenosine analog, as a potential therapeutic agent for colon cancer. The researchers investigated Cl-F-araA's antitumor activity against human colon tumor xenografts, revealing its potential to inhibit DNA synthesis and suppress tumor growth.
A New Frontier in Colon Cancer Therapy
The discovery of Cl-F-araA, like finding a hidden oasis in the vast desert of cancer research, offers a potential new weapon in the fight against colon cancer. The study's findings suggest that Cl-F-araA could be a promising therapeutic agent for treating colon cancer, providing hope for patients seeking effective treatments.
Unlocking New Treatment Options for Colon Cancer
Colon cancer, like a stubborn desert sandstorm, can be a challenging condition to treat. This research provides a glimmer of hope for patients, unveiling the potential of Cl-F-araA as a new therapeutic option. Further clinical trials are needed to evaluate the safety and efficacy of Cl-F-araA in treating colon cancer, but the initial findings are encouraging.
Dr.Camel's Conclusion
This research on Cl-F-araA presents a promising new avenue for colon cancer treatment. It's like discovering a hidden spring in the desert, offering a source of hope for patients seeking effective therapies. Further research will be crucial to determine the full potential of this novel deoxyadenosine analog in treating colon cancer.
Date :
- Date Completed 1999-02-04
- Date Revised 2019-08-31
Further Info :
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