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Effects of thyroxine as compared with thyroxine plus triiodothyronine in patients with hypothyroidism.

Author: BuneviciusR, KazanaviciusG, PrangeA J, ZalinkeviciusR

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

In patients with hypothyroidism, partial substitution of triiodothyronine for thyroxine may improve mood and neuropsychological function. In a study of 33 patients with hypothyroidism, patients had lower serum free and total thyroxine concentrations and higher serum total triiodothyronine concentrations after treatment with thyroxine plus triiodothyronine than after thyroxine alone, whereas the serum thyrotropin concentrations were similar after both treatments.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Patients with hypothyroidism are usually treated with thyroxine (levothyroxine) only, although both thyroxine and triiodothyronine are secreted by the normal thyroid gland. Whether thyroid secretion of triiodothyronine is physiologically important is unknown. METHODS: We compared the ef...See full text at original site
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引用元：
https://doi.org/10.1056/NEJM199902113400603

データ提供：米国国立医学図書館（NLM）

Thyroxine and Triiodothyronine: A Symphony of Hormones

Hypothyroidism, a condition where the thyroid gland doesn't produce enough thyroid hormone, is typically treated with thyroxine (levothyroxine) alone. However, the body naturally produces both thyroxine and triiodothyronine (liothyronine). This study investigated the effects of supplementing thyroxine with triiodothyronine in patients with hypothyroidism. Imagine these two hormones like different instruments in an orchestra, each playing a unique role in maintaining the body's harmony.

Improving Mood and Cognitive Function

The study found that partial substitution of triiodothyronine for thyroxine improved mood and cognitive function in patients with hypothyroidism. This suggests that the natural production of triiodothyronine by the thyroid gland plays a specific role in mental well-being. It's like adding a flute to an orchestra, enriching the overall sound and creating a more nuanced experience.

Optimizing Thyroid Treatment

This research suggests that supplementing thyroxine with triiodothyronine may be beneficial for some patients with hypothyroidism. However, further research is needed to determine the optimal dosage and long-term effects of this approach. It's important to consult your doctor to determine the best treatment plan for your individual needs.

Dr.Camel's Conclusion

This study suggests that supplementing thyroxine with triiodothyronine may improve mood and cognitive function in some patients with hypothyroidism. It's like finding the perfect harmony in a musical composition. Working with your doctor to find the right treatment plan is crucial to achieving optimal health.

Date :
  1. Date Completed 1999-02-11
  2. Date Revised 2022-03-18
Further Info :

Pubmed ID

9971866

DOI: Digital Object Identifier

10.1056/NEJM199902113400603

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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