Major Research Findings

Abaloparatide has been considered as an alternative to teriparatide since 2017 as a drug for treating postmenopausal osteoporosis. 2 . Abaloparatide is an analog of human recombinant parathyroid hormone protein (PTHrp) and has been shown to have a bone-forming effect. 2 . It has been found that abaloparatide treatment can significantly promote pre-osteoblast MC3T3-E1 cell viability, differentiation, and mineralization in vitro. 2 . Also, encapsulating abaloparatide in methacrylated gelatin (GelMA) hydrogel was found to be effective in prolonging the release of abaloparatide (more than 10 days). 2 . In a rat study, abaloparatide-loaded GelMA hydrogel was suggested to promote bone regeneration. 2 .

Reasons for Side Effects

Side effects of abaloparatide are due to its bone-forming effect. Excessive bone formation can increase bone density and hardness. Also, the promotion of bone formation can activate bone metabolism and accelerate bone resorption. This acceleration of bone resorption is thought to be responsible for some side effects.

Common Side Effects

Headache

Headache is one of the common side effects of abaloparatide and teriparatide. 1 . Headache is thought to be caused by the acceleration of bone resorption due to the activation of bone metabolism by the promotion of bone formation.

Nausea

Nausea is also one of the common side effects of abaloparatide and teriparatide. 1 . Nausea is thought to be caused by the acceleration of bone resorption due to the activation of bone metabolism by the promotion of bone formation.

Measures for Side Effects

Headache

If you experience a headache, please consult your doctor. If the cause of the headache is abaloparatide, measures such as discontinuing or reducing the dosage of the drug may be considered.

Nausea

If you feel nauseous, try to eat small meals. Taking an antiemetic can also be effective. If your symptoms do not improve, consult your doctor.

Comparison between Studies

Common Points of the Studies

Both studies showed that abaloparatide has a bone-forming effect. Both studies also suggested that abaloparatide could be effective in treating osteoporosis.

Differences between Studies

Study 1 showed that abaloparatide, like teriparatide, significantly reduces vertebral and non-vertebral fractures. Study 2 showed that encapsulating abaloparatide in GelMA hydrogel improves sustained release and has a bone regeneration-promoting effect.

Points to Note for Application to Real Life

Abaloparatide is an effective drug for the treatment of osteoporosis, but it is important to be aware of the risk of side effects. Before taking abaloparatide, consult your doctor and understand the risks and benefits of taking it.

Limitations of Current Research

The long-term safety and efficacy of abaloparatide have not been fully elucidated. Further research is important to assess the long-term safety of abaloparatide and develop more effective treatments.

Future Research Directions Needed

Further research is needed on the long-term safety and efficacy of abaloparatide and the optimal dosage. Further research is also needed to see if abaloparatide is more effective when combined with other osteoporosis treatments.

Conclusion

Abaloparatide has been shown to have a bone-forming effect and has the potential to be effective in the treatment of osteoporosis. However, there is also a risk of side effects, so it is important to consult your doctor and understand the risks and benefits of taking it.