Effects of acetaminophen: A Synthesis of Findings from 1 Studies

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Original Abstract of the Article

Main Research Findings

This study investigated the subjective, psychomotor, and physiological effects of two commonly prescribed doses of hydrocodone/acetaminophen and oxycodone/acetaminophen combination products in healthy volunteers. The study found that both combination products produced dose-dependent subjective, psychomotor, and physiological effects. Hydrocodone/acetaminophen and oxycodone/acetaminophen combination products affected various parameters including pain relief, sleepiness, mood elevation, fatigue, mood changes, concentration, cognitive function, balance, reaction time, heart rate, and blood pressure. Both products showed dose-dependent effects, with oxycodone/acetaminophen demonstrating stronger effects compared to hydrocodone/acetaminophen. These findings highlight the importance of understanding the efficacy and safety profiles of hydrocodone/acetaminophen and oxycodone/acetaminophen combination products. 1

Benefits and Risks

Benefit Summary

These combination products may be helpful in reducing moderate to severe pain. 1

Risk Summary

These combination products can cause various side effects such as drowsiness, mood elevation, fatigue, mood changes, decreased concentration, cognitive function, balance, and reaction time, as well as increased heart rate and blood pressure. 1

Comparison Across Studies

Commonalities Across Studies

This study was conducted on healthy volunteers to assess the efficacy and safety of hydrocodone/acetaminophen and oxycodone/acetaminophen combination products. 1

Differences Across Studies

This study was conducted on healthy volunteers to compare the efficacy and safety of hydrocodone/acetaminophen and oxycodone/acetaminophen combination products. 1

Consistency and Discrepancies in Results

This study demonstrated that hydrocodone/acetaminophen and oxycodone/acetaminophen combination products produced dose-dependent subjective, psychomotor, and physiological effects. 1

Practical Implications and Cautions

When taking these combination products, it's crucial to be aware of potential side effects such as drowsiness, mood elevation, fatigue, mood changes, decreased concentration, cognitive function, balance, and reaction time, as well as increased heart rate and blood pressure. 1

Limitations of the Current Study

This study was conducted on healthy volunteers, so it's unclear if these results can be applied to patients experiencing chronic pain. Additionally, this study was short-term, preventing conclusions about long-term effects. 1

Future Research Directions

Long-term studies with patients experiencing chronic pain are needed. Research should also investigate interactions with other medications to evaluate the efficacy and safety of these combination products. 1

Conclusion

Hydrocodone/acetaminophen and oxycodone/acetaminophen combination products demonstrate pain-relieving effects but can cause various side effects. It's essential to follow your doctor's instructions and be vigilant for potential side effects when using these products. 1

Keywords
Benefit Keywords
Risk Keywords
Miosis
Psychomotor impairment
Subjective effects
1
Literature analysis of 1 papers
Positive Content
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Neutral Content
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Negative Content
1
Article Type
1
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1
1.

Subjective, psychomotor, and physiological effects profile of hydrocodone/acetaminophen and oxycodone/acetaminophen combination products.

Author: ZacnyJames P, GutierrezSandra

Miosis
Psychomotor impairment
Subjective effects

In a study of 16 healthy volunteers, oxycodone/acetaminophen produced a wider spectrum of subjective effects than hydrocodone/acetaminophen at the 10 mg opioid dose. Both drug combinations impaired psychomotor performance at the 10 mg opioid dose.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

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