Side Effects of acetaminophen rectal: A Synthesis of Findings from 16 Studies

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Original Abstract of the Article

Main Research Findings

Acetaminophen suppositories are widely used in children and adults to reduce pain after surgery, such as tonsillectomy and cesarean section. 15 , 2 , 6 , 1 , 5 , 8 , 9 , 11 , 7 , 4 , 14 , 12 , 3 , 16 , 10 , 13 These studies suggest that acetaminophen suppositories are effective in reducing post-operative pain. Also, it has been found that acetaminophen suppositories are effective in children's fever. 9 , 7 Acetaminophen suppositories may be a good option for children and patients who have difficulty taking oral medication, as they have fewer side effects than oral administration. 5

Reasons for Side Effects

Side effects of acetaminophen suppositories may be due to side effects of acetaminophen itself or side effects due to the suppository base. 14

Common Side Effects

Digestive System

The most common side effect of acetaminophen suppositories is digestive system side effects. Studies have shown that using acetaminophen suppositories can lead to side effects such as nausea, vomiting, abdominal pain, and diarrhea. 1 , 8 , 12

Skin

Using acetaminophen suppositories can cause skin side effects such as itching and rash. 12

Other

Using acetaminophen suppositories can cause side effects such as headache, dizziness, and fever. 12

Countermeasures for Side Effects

Digestive System

To reduce digestive system side effects, it is important to drink plenty of fluids when taking acetaminophen suppositories. 12 Also, taking acetaminophen suppositories after meals may reduce digestive system side effects. 12

Comparison of Studies

Common Points of Studies

Many studies suggest that acetaminophen suppositories are effective in reducing post-operative pain and fever. 15 , 2 , 6 , 1 , 5 , 8 , 9 , 11 , 7 , 4 , 14 , 12 , 3 , 16 , 10 , 13

Differences in Studies

The incidence and type of side effects of acetaminophen suppositories vary depending on the study. 1 , 12

Points to Note Regarding Application to Real Life

Acetaminophen suppositories can be an effective treatment for reducing post-operative pain and fever. 15 , 2 , 6 , 1 , 5 , 8 , 9 , 11 , 7 , 4 , 14 , 12 , 3 , 16 , 10 , 13 However, it is important to remember that there is a risk of side effects when using acetaminophen suppositories. 1 , 12 If you experience any side effects from acetaminophen suppositories, consult your doctor. 1 , 12

Limitations of Current Research

Research on acetaminophen suppositories is still insufficient. In particular, more research is needed on long-term side effects. 1 , 12

Future Research Directions

More research is needed to assess the long-term safety and efficacy of acetaminophen suppositories. 1 , 12 Further research is also needed on the optimal dosage and administration methods of acetaminophen suppositories. 1 , 12

Conclusion

Acetaminophen suppositories can be an effective treatment for reducing post-operative pain and fever. 15 , 2 , 6 , 1 , 5 , 8 , 9 , 11 , 7 , 4 , 14 , 12 , 3 , 16 , 10 , 13 However, it is important to remember that there is a risk of side effects when using acetaminophen suppositories. 1 , 12 If you experience any side effects from acetaminophen suppositories, consult your doctor. 1 , 12

Literature analysis of 16 papers
Positive Content
14
Neutral Content
0
Negative Content
2
Article Type
5
0
0
1
16
1.

Tramadol suppositories are less suitable for post-operative pain relief than rectal acetaminophen/codeine.

Author: PluimM A, WegenerJ T, RuprehtJ, VultoA G

Postoperative pain relief
Nausea
Vomiting

Tramadol suppositories were less effective than acetaminophen/codeine suppositories for post-operative pain due to a significantly higher incidence of nausea and vomiting (84% vs. 31%).

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Comparison of oral versus rectal administration of acetaminophen with codeine in postoperative pediatric adenotonsillectomy patients.

Author: OwczarzakVicki, HaddadJoseph

Improved pain control

Rectal acetaminophen with codeine suppositories were an effective alternative for pain control after adenotonsillectomy, achieving equivalent pain control as oral medication with few side effects and good tolerance. Parents found the suppositories easy to administer.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

[Postoperative pain therapy after tonsillectomy in children. An observational study for 7 days].

Author: FöselT, FötschS, EbelingO

Reduced pain
Postoperative haemorrhage

A specific protocol for pain therapy after tonsillectomy in children was found to be effective in reducing pain intensity and minimizing side effects such as vomiting and postoperative hemorrhage.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : German

4.

Morphine consumption in patients receiving rectal paracetamol and diclofenac alone and in combination.

Author: MontgomeryJ E, SutherlandC J, KestinI G, SneydJ R

Postoperative pain treatment

A combination of diclofenac and paracetamol reduced morphine consumption compared with paracetamol alone in patients undergoing elective abdominal gynecological surgery. There was no difference in the incidence of morphine-related side effects between the groups.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

7.

Rectal Diclofenac Versus Rectal Paracetamol: Comparison of Antipyretic Effectiveness in Children.

Author: SharifMohammad Reza, Haji RezaeiMostafa, AalinezhadMarzieh, SaramiGolbahareh, RangrazMasoud

Antipyretic effects
Toxicity

This study explored the use of diclofenac as an antipyretic drug in children. While paracetamol is the most common antipyretic drug, it has serious side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

8.

Painless dental extraction in children.

Author: ElhakimM

Improved analgesia
Shorter recovery period

Topical lignocaine was more effective than rectal paracetamol in preventing pain after day case dental extraction in children under general anaesthesia, leading to significantly lower pain scores, a more rapid return to a calm awake appearance, and no need for postoperative analgesia.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

9.

[Hyperthermia in children, efficacy of a drinkable solution of paracetamol].

Author: GautryP, BussereauM

Reduces fever

A new presentation of a drug for pediatric patients resulted in a significant decrease in body temperature in 29 children, with no undesirable side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : French

11.

The analgesic effects of rectal diclofenac versus rectal paracetamol following caudal-bupivacaine for pediatric day-case inguinal herniotomies: a randomized controlled prospective trial.

Author: NnajiChimaobi T, Onajin-ObembeBisola, EbirimLonginus

Postoperative pain management

This study compared the postoperative analgesic effects of caudal-bupivacaine and rectal diclofenac versus caudal-bupivacaine and rectal-paracetamol in children undergoing day-case inguinal herniotomy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

14.

Pharmacokinetics of propylene glycol after rectal administration.

Author: KollöffelW J, WeekersL E, GoldhoornP B

Local side effects
Systemic side effects

This study investigated the pharmacokinetics and potential side effects of propylene glycol after rectal administration. Propylene glycol was well absorbed after rectal administration in both adults and children.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

16.

[Familial use of ibuprofen in febrile children: a prospective study in the emergency room of an hospital in Lille].

Author: CharkalukM L, KalachN, El KohenR, KrempO

Fever treatment
Side effects

Ibuprofen was widely used in children with fever, but its use should be limited to cases of high and poorly tolerated fever not responsive to acetaminophen monotherapy due to potential side effects.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : French

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