Effects of adagrasib: A Synthesis of Findings from 3 Studies

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Original Abstract of the Article

Major Research Findings

Albendazole has been shown to be an effective treatment for various parasitic infections. A study involving 112 patients with gnathostomiasis found that albendazole, administered at a dosage of 400mg twice daily or once daily, led to cure in 93.9% and 94.1% of patients, respectively, compared to none in the placebo group. 1 . Additionally, a placebo-controlled study involving 870 patients with intestinal helminthiasis demonstrated high efficacy of albendazole against roundworms and tapeworms. 2 . However, albendazole has also been linked to liver injury. A systematic review encompassing 12 cases reported jaundice, anorexia, and vomiting as common symptoms following albendazole use, with elevated liver enzymes observed in all cases. 3 .

Benefits and Risks

Benefit Summary

Albendazole is a widely used antiparasitic medication that has demonstrated efficacy in treating gnathostomiasis, various intestinal helminth infections, and even strongyloidiasis. 1 , 2 . The drug generally exhibits minimal side effects, which are often temporary. 1 , 2 .

Risk Summary

Albendazole use carries a risk of liver injury, even at relatively low doses. 3 . Symptoms such as jaundice, anorexia, and vomiting have been reported in individuals following albendazole administration. 3 .

Comparison Across Studies

Commonalities

All three studies focused on evaluating the efficacy and safety of albendazole. 1 , 2 , 3 . They consistently demonstrated the effectiveness of albendazole in treating parasitic infections. 1 , 2 , 3 .

Differences

The studies differed in their target diseases and administration methods. 1 investigated the treatment of gnathostomiasis, while 2 focused on various intestinal helminth infections. 3 specifically evaluated the risk of liver injury associated with albendazole use.

Consistency and Contradictions

While all three studies indicated the effectiveness of albendazole, one study highlighted the potential for liver injury as a side effect. 3 . It's crucial to recognize this risk and follow medical advice closely when using albendazole.

Practical Implications and Cautions

It's essential to adhere to medical guidance when using albendazole, as self-administration can increase the risk of liver injury. 3 . Additionally, pregnant and breastfeeding women should avoid albendazole use. 1 , 2 .

Current Research Limitations

Further research is needed to assess the long-term effectiveness and safety of albendazole. 1 , 2 , 3 . Additional research is also crucial to develop strategies for minimizing the risk of side effects associated with albendazole use.

Future Research Directions

Future research should focus on the long-term effects and safety of albendazole, strategies to minimize side effects, and its safety during pregnancy and breastfeeding.

Conclusion

Albendazole is an effective treatment for a range of parasitic infections. 1 , 2 . However, it's essential to be aware of the risk of liver injury. 3 . Always follow medical guidance when using albendazole to minimize the risk of side effects.

Literature analysis of 3 papers
Positive Content
2
Neutral Content
0
Negative Content
1
Article Type
2
0
1
0
3
1.

Albendazole for the treatment of human gnathostomiasis.

Author: KraivichianP, KulkumthornM, YingyourdP, AkarabovornP, PaireepaiC C

Effective treatment
Minimal side effects

Albendazole was effective in treating gnathostomiasis in 112 patients. 93.9% and 94.1% of the patients who received albendazole were cured compared to none of the placebo group. Albendazole also reduced eosinophil counts and immunoglobulin G antibody levels. Side effects were minimal.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

Albendazole: placebo-controlled study in 870 patients with intestinal helminthiasis.

Author: RossignolJ F, MaisonneuveH

Effective against parasites
No significant side effects

A single 400mg dose of albendazole was highly effective against Ascaris lumbricoides, Necator americanus, Ancylostoma duodenale and Trichuris trichiura, and it showed efficacy against Strongyloides stercoralis after 3 consecutive days. It also had fair efficacy against Hymenolepis nana. The drug did not have any significant side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

Albendazole-Induced Liver Injury.

Author: PiloiuClaudia, DumitrascuDan L

Antiparasitic treatment
Liver injury

Albendazole may induce liver injury, even in small doses, and practitioners and patients should be aware of this risk.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

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