Side Effects of adalimumab injection: A Synthesis of Findings from 2 Studies

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Original Abstract of the Article

Major Findings

Albendazole is an anthelmintic drug used worldwide for prophylactic or curative treatment. 1 . Adalimumab is a tumor necrosis factor alpha (TNF-α) inhibitor widely used for many autoimmune disorders. 2 . However, they cause an immunocompromised status that sometimes leads to many cutaneous side effects, including atypical infections. 2 .

Reasons for Side Effects

Albendazole is metabolized in the liver, so it can have side effects on the liver. 1 . Adalimumab has immunosuppressive effects, which can increase the risk of skin infections. 2 .

Common Side Effects

Albendazole

Side effects of albendazole include diarrhea, abdominal pain, elevated levels of hepatic transaminases, dizziness, neutropenia, and alopecia. 1 .

Adalimumab

Side effects of adalimumab include skin infections, such as Majocchi's granuloma. 2 .

Side Effect Management

Albendazole

To reduce the side effects of albendazole, it is important to follow your doctor's instructions and take the correct dosage. 1 . Also, if you experience any side effects, consult your doctor immediately.

Adalimumab

To reduce the side effects of adalimumab, it is important to be aware of the signs of skin infections and seek treatment as needed. 2 .

Comparison of Studies

Commonalities

Both studies indicate that albendazole and adalimumab can cause side effects on the liver and skin, respectively. 1 , 2 .

Differences

While albendazole can cause side effects on the liver, adalimumab can cause skin infections. 1 , 2 .

Practical Applications and Precautions

If you are using albendazole or adalimumab, it is important to follow your doctor's instructions and be aware of the signs of side effects. 1 , 2 . If you experience any side effects, consult your doctor immediately.

Limitations of Current Research

Both studies provide limited information on the side effects of albendazole and adalimumab, so further research is needed. 1 , 2 .

Future Research Directions

Further research is needed to better understand the side effects of albendazole and adalimumab. 1 , 2 .

Conclusion

Albendazole and adalimumab can cause side effects on the liver and skin, respectively. 1 , 2 . It is important to follow your doctor's instructions and be aware of the signs of side effects if you are using these drugs. 1 , 2 . If you experience any side effects, consult your doctor immediately.

Literature analysis of 2 papers
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1.

Albendazole-Induced Liver Injury.

Author: PiloiuClaudia, DumitrascuDan L

Antiparasitic treatment
Liver injury

Albendazole may induce liver injury, even in small doses, and practitioners and patients should be aware of this risk.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

2.

A Case Report of Majocchi's Granuloma Associated with Combined Therapy of Topical Steroids and Adalimumab.

Author: ChouWan-Yi, HsuChih-Jung

Autoimmune disorder treatment
Atypical infections
Cutaneous side effects

Adalimumab, a TNF-alpha inhibitor, can cause immunocompromised status and atypical infections, including Majocchi's granuloma. This case report describes a 43-year-old male with psoriasis who developed Majocchi's granuloma after adalimumab injection. The nodules responded poorly to bacterial folliculitis treatment but improved dramatically after adalimumab withdrawal and terbinafine treatment for 12 weeks. It is crucial to examine psoriasis patients for latent dermatophyte infection before and during treatment with TNF-alpha inhibitors to prevent atypical infections and treatment failures.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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