Effective treatment of addison disease: A Synthesis of Findings from 24 Studies

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Original Abstract of the Article

Major Research Findings

This study investigated the short-term effects of platelet-rich plasma (PRP) in the treatment of chronic anal fissure. The study was a randomized controlled clinical trial, comparing PRP injections with standard medical treatments for anal fissure. 1 .

Treatment Summary

This study focused on the treatment of chronic anal fissure, a common condition that causes pain and discomfort. The researchers evaluated the effectiveness of PRP injections as a treatment option compared to standard medical treatments. 1 .

Benefits and Risks

Benefit Summary

PRP treatment may be an effective option for treating chronic anal fissure, offering potential benefits such as reduced pain and improved healing. 1 .

Risk Summary

While PRP treatment may be beneficial, it's essential to understand potential risks, such as injection site pain, swelling, or other complications. 1 .

Comparison of Studies

Similarities

This study provides valuable information on the potential of PRP treatment for chronic anal fissure, contributing to the body of knowledge on this condition. 1 .

Differences

This study was specifically focused on the short-term results of PRP treatment for chronic anal fissure. 1 .

Consistency and Contradictions of Results

The study suggests that PRP treatment holds promise for treating chronic anal fissure. 1 .

Practical Implications

If you are experiencing chronic anal fissure, it's important to consult with a healthcare professional to discuss treatment options. 1 .

Limitations of Current Research

This study only evaluated the short-term effects of PRP treatment. Further research is needed to understand the long-term effects, effectiveness, and safety of this treatment option. 1 .

Future Research Directions

Future research should investigate the long-term effectiveness and safety of PRP treatment for chronic anal fissure. 1 .

Conclusion

This study provides evidence that PRP treatment may be a viable option for treating chronic anal fissure. However, more research is required to confirm its long-term benefits and ensure its safe and effective application. 1 .

List of Treatments

Platelet-rich plasma (PRP) injection

Literature analysis of 24 papers
Positive Content
19
Neutral Content
2
Negative Content
2
Article Type
1
0
1
4
23
1.

Short-term Results of Platelet-Rich Plasma in the Treatment of Chronic Anal Fissure: Randomized Controlled Clinical Study.

Author: YilmazGökhan, TanrikuluYusuf

Accelerated healing
Reduced pain

Platelet-rich plasma reduced pain and accelerated epithelialization and healing in patients with chronic anal fissures compared to topical glyceryl trinitrate.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Video-Audio MediaMedia that combines video and audio. Includes movies, TV shows, and online videos.

Language : English

2.

Pediatric Adrenal Insufficiency: Challenges and Solutions.

Author: NisticòDaniela, BossiniBenedetta, BenvenutoSimone, PellegrinMaria Chiara, TorneseGianluca

Adrenal insufficiency diagnosis
Glucocorticoid replacement

Adrenal insufficiency is a condition where the adrenal glands don't produce enough cortisol, which can lead to serious health problems. This condition can be difficult to diagnose, especially in children. Treatment involves long-term glucocorticoid replacement therapy, with oral hydrocortisone being the preferred option. Acute adrenal crisis is a life-threatening condition, and prompt treatment is essential.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

3.

Endocrine adverse events related with immune checkpoint inhibitors: an update for clinicians.

Author: DeligiorgiMaria V, PanayiotidisMihalis I, TrafalisDimitrios T

Cancer treatment
Immune response enhancement
Endocrine immune-related adverse events

Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment but can also lead to endocrine immune-related adverse events (irAEs). These irAEs are characterized by unpredictable onset, irreversibility, and a wide clinical spectrum. Early detection and management are crucial for optimizing ICI therapy and minimizing immunotoxicity.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

5.

[Hyperpigmentation reveals Addison's disease in a pregnant woman].

Author: DanielsenElisabeth, HansenJuliana Frohnert, KloseMarianne, WormDorte

Adrenal insufficiency treatment
Diagnosis difficulty

Primary adrenal insufficiency during pregnancy can be difficult to diagnose as many symptoms overlap with normal pregnancy symptoms. This case report describes a 31-year-old woman diagnosed with primary adrenal insufficiency during pregnancy due to the presence of hyperpigmentation.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Danish

6.

Immune Checkpoint Inhibitor-Associated Primary Adrenal Insufficiency: WHO VigiBase Report Analysis.

Author: GrouthierVirginie, Lebrun-VignesBénédicte, MoeyMelissa, JohnsonDouglas B, MoslehiJavid J, SalemJoe-Elie, BachelotAnne

Cancer therapy
Immune-related adverse events

This study aims to identify and characterize the main features of primary adrenal insufficiency (PAI) as an immune-related adverse event (irAE) associated with immune checkpoint inhibitors (ICIs) treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

7.

Systemic lupus erythematosus and antiphospholipid antibody syndrome associated Addison disease: A case report.

Author: LiZhilan, PengYi, ZhangWeiru, XieYanli

Addison disease management
Antiphospholipid antibody syndrome management
Adrenal crisis

This case report describes a middle-aged female diagnosed with Addison disease, antiphospholipid antibody syndrome secondary to systemic lupus erythematosus. The patient presented with symptoms of adrenal insufficiency and was successfully treated with hormone, anti-infective, and anticoagulant therapy. The report highlights the importance of considering adrenal damage in patients with connective tissue diseases and recognizing the potential for adrenal crisis.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

10.

Autoimmune Polyglandular Syndrome type 2.

Author: MartinsSofia Costa, VenadeGabriela, TeixeiraMónica, OlivérioJoão, MachadoJoão, MarquesJoana, MatosLuís Costa

Addison's disease treatment

This case report describes a 42-year-old woman who was diagnosed with Addison’s disease, an autoimmune disorder that affects the adrenal glands. The patient also had a history of Graves’ disease and type 2 diabetes mellitus, which are both autoimmune diseases.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

11.

Increased resting-state functional connectivity in patients with autoimmune Addison's disease.

Author: Van't WesteindeAnnelies, PadillaNelly, Fletcher-SandersjööSara, KämpeOlle, BensingSophie, LajicSvetlana

AAD hormone replacement
AAD brain health impact

This review discusses the impact of autoimmune Addison's disease (AAD) on brain health. It highlights the importance of addressing the brain's sensitivity to adrenal hormones and the need for further research in this area.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

12.

Primary adrenal insufficiency due to adrenal tuberculosis: a case report.

Author: YuJie, LuYingli, HanBing

This case report describes a 51-year-old woman diagnosed with primary adrenal insufficiency due to adrenal tuberculosis, with no evidence of active tuberculosis in her lungs. The patient improved after 15 months of treatment with anti-tuberculosis drugs and cortisol replacement therapy.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

13.

Immune Checkpoint Inhibitor-Induced Adrenalitis and Primary Adrenal Insufficiency: Systematic Review and Optimal Management.

Author: ShiYun, ShenMin, ZhengXuqin, YangTao

cancer treatment
adrenal insufficiency
adrenalitis

Immune checkpoint inhibitors (ICIs) are associated with a risk of immune-related adverse events, including adrenalitis and primary adrenal insufficiency (PAI). This study reviews reported cases of these rare but lethal endocrine immune-related adverse events in patients who underwent ICI therapy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

14.

Autoimmune Thyroid Disorders in Autoimmune Addison Disease.

Author: Meling StoklandAnn-Elin, UelandGrethe, LimaKari, GrønningKaja, FinnesTrine E, SvendsenMargrethe, Ewa TomkowiczAneta, Emblem HolteSynnøve, Therese SollidStina, DebowskaAleksandra, SingsåsHallvard, Landsverk RensvikMarthe, LejonHelle, SørmoDag-Erik, SvareAnders, BlikaSigrid, MilovaPetya, KorsgaardElin, HusbyØystein, BreivikLars, JørgensenAnders P, Sverre HusebyeEystein

Comparable outcomes
Long-term remission
Hypothyroidism in AAD
Levothyroxine therapy

This nationwide registry-based study investigated the prevalence and clinical course of autoimmune thyroid disorders in patients with autoimmune Addison disease (AAD). Autoimmune thyroid disease was diagnosed in 48% of AAD patients. Careful consideration of the indication to start thyroxine therapy is warranted. Long-term remission rates in Graves disease (GD) patients with AAD were comparable to recent reports in patients without AAD.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

15.

Major immunophenotypic abnormalities in patients with primary adrenal insufficiency of different etiology.

Author: NowotnyHanna F, Marchant SeiterThomas, JuJing, GottschlichAdrian, SchneiderHolger, ZoppStephanie, VogelFrederick, TschaidseLea, AuerMatthias K, LottspeichChristian, KoboldSebastian, RothenfusserSimon, BeuschleinFelix, ReinckeMartin, BraunLeah, ReischNicole

PAI management
Immune cell dysregulation

This study examines the immune landscape of patients with primary adrenal insufficiency (PAI) to understand immune cell dysregulation associated with glucocorticoid (GC) deficiency.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

16.

Psychotic Disorder as the First Manifestation of Addison Disease: A Case Report.

Author: Momayez SanatZahra, Mohajeri-TehraniMohammad Reza

Addison's disease diagnosis
Early treatment
Neuropsychiatric symptoms
Psychotic disorder

Psychotic disorder can be the first manifestation of Addison's disease. Physicians should be aware of the neuropsychiatric symptoms of adrenal insufficiency.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.

Language : English

18.

Autoimmune adrenal insufficiency in children: a hint for polyglandular syndrome type 2?

Author: ArrigoniMarta, CavarzerePaolo, Nicolussi PrincipeLara, GaudinoRossella, AntoniazziFranco

Primary adrenal insufficiency treatment

Primary adrenal insufficiency (PAI) is a serious condition that affects children. Autoimmune adrenalitis is a rare cause of PAI in children and may present as an isolated disorder or as part of autoimmune polyglandular syndrome (APS) type 2.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

19.

Self-management and hospitalization in 615 Swedish patients with Addison's disease during the coronavirus disease 2019 pandemic: a retrospective study.

Author: ÖsterSara, EspositoDaniela, Aranda-GuillénMaribel, ÅkermanAnna-Karin, WahlbergJeanette, HusebyeEystein Sverre, KämpeOlle, BotusanIleana Ruxandra, DahlqvistPer, BergthorsdottirRagnhildur, BensingSophie

COVID-19 risk

This study investigates the incidence of COVID-19 in patients with autoimmune Addison's disease (AAD) in Sweden. It examines self-adjustment of medications, social impacts, and treatment during hospitalization, and investigates possible risk factors for infection and hospitalization.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

20.

Sex-disease dimorphism underpins enhanced motion sickness susceptibility in primary adrenal insufficiency: a cross-sectional observational study.

Author: SamanYougan, SharifMishaal, LeeAbigail, AhmedShiza, PagánAscensión, McGuirkMaggie, ReaOliver, PatelRakesh, BuntingFreya, SpenceCaitlin, YoonHa-Jun, Mukaetova-LadinskaElizabeta, ReaPeter, KheradmandAmir, GoldingJohn, ArshadQadeer

Motion sickness

Patients with primary adrenal insufficiency, who typically have altered ACTH levels, may exhibit alterations in motion sickness susceptibility. This study found that motion sickness susceptibility pre-diagnosis did not differ between controls and patients. However, following treatment, current measures of motion sickness were significantly increased in patients, especially in female patients with primary adrenal insufficiency. This suggests a complex sex-disease-drug interaction.

Observational StudyResearch that observes and collects data on participants' behavior and outcomes in their natural state, without intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

21.

Effects of the therapy shift from cortisone acetate to modified-release hydrocortisone in a group of patients with adrenal insufficiency.

Author: FrigerioSofia, CarosiGiulia, FerranteEmanuele, SalaElisa, PolledriElisa, FustinoniSilvia, AmbrosiBruno, ChiodiniIacopo, MantovaniGiovanna, MorelliValentina, ArosioMaura

Improved metabolic control
Improved quality of life

This study assessed the clinical and biochemical modifications in patients with adrenal insufficiency (AI) who were switched from cortisone acetate (CA) to modified-release hydrocortisone (MRH). MRH provides a more physiological cortisol rhythm, potentially improving metabolic control and quality of life.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

23.

Pulsatile Subcutaneous Hydrocortisone Replacement in Primary Adrenal Insufficiency.

Author: SimunkovaKaterina, LøvåsKristian, MethliePaal, JovanovicNevena, BifulcoErsilia, BronstadIngeborg, LightmanS L, HusebyeEystein Sverre, OksnesMarianne

Adrenal insufficiency treatment

This study compared pulsatile and continuous cortisol pump treatment with conventional oral glucocorticoid therapy in five patients with adrenal insufficiency. The results showed that pulsatile pump treatment was superior to both continuous pump and oral therapy in maintaining normal ACTH levels throughout the 24-h cycle.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

24.

Endocrine complications of immunotherapies: a review.

Author: HattersleyRosie, NanaMelanie, LansdownAndrew J

Increased survival
Endocrine side effects

Immune checkpoint inhibitors are drugs that help the body fight cancer. They can cause side effects in about 10% of patients, including thyroid problems, pituitary gland inflammation, diabetes, and adrenal gland problems.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

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