Effects of aliskiren: A Synthesis of Findings from 5 Studies

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Original Abstract of the Article

Major Research Findings

Aliskiren is a direct renin inhibitor approved for the treatment of hypertension. 1 Several studies have investigated its effects on kidney health, cardiovascular outcomes, and drug interactions. 3 found that aliskiren, while not significantly impacting serum creatinine or estimated glomerular filtration rate, can reduce proteinuria and albuminuria, potentially providing kidney protection. Furthermore, the combination of aliskiren with ACEI or ARB demonstrated a more pronounced reduction in proteinuria and albuminuria compared to monotherapy. 3 2 examined the impact of aliskiren on cardiovascular outcomes in prehypertensive patients, finding no significant effects. However, a meta-analysis of 13,395 patients with diabetes and cardiovascular disease or risk factors showed that while aliskiren didn't affect mortality or cardiovascular events, it increased the risk of hyperkalemia and renal impairment. 4 5

Benefits and Risks

Benefit Summary

Aliskiren might offer kidney protection by reducing proteinuria and albuminuria. 3 This effect can be enhanced when combined with ACEI or ARB. 3 Moreover, aliskiren does not appear to significantly interact with acenocoumarol, a blood thinner. 1

Risk Summary

Aliskiren may increase the risk of hyperkalemia and renal impairment. 4

Comparison Across Studies

Commonalities

Multiple studies agree that aliskiren does not significantly affect serum creatinine or estimated glomerular filtration rate. 3 4 Similarly, several studies have observed a reduction in proteinuria and albuminuria with aliskiren treatment. 3 4

Differences

The impact of aliskiren on cardiovascular events is inconsistent across studies. While 2 found no significant effect in prehypertensive patients, 4 reported no impact on mortality or cardiovascular events but observed increased risks of hyperkalemia and renal impairment in patients with diabetes and cardiovascular disease or risk factors.

Consistency and Contradictions

Research findings suggest that aliskiren might have a protective effect on the kidneys. 3 4 However, the influence of aliskiren on cardiovascular events is inconsistent across studies. 2 4 Furthermore, it's crucial to acknowledge the potential risks associated with aliskiren, including increased hyperkalemia and renal impairment. 4

Practical Applications and Precautions

While aliskiren may be used for hypertension treatment and might offer kidney protection, 3 it's essential to consider the potential risks of hyperkalemia and renal impairment. 4 Individuals with these risk factors should use aliskiren with caution. Consulting a healthcare professional is crucial before starting any new medication, including aliskiren.

Limitations of Current Research

The impact of aliskiren on cardiovascular events requires further investigation due to inconsistent findings across studies. 2 4

Future Research Directions

More research is necessary to clarify the impact of aliskiren on cardiovascular events. Further investigation into the mechanisms by which aliskiren potentially protects the kidneys is also needed.

Conclusion

Aliskiren, a medication used for hypertension, may offer kidney protection. 3 However, it's important to be aware of the potential risks of hyperkalemia and renal impairment associated with its use. 4 If you have these risk factors, use aliskiren with caution and consult your doctor before starting any new medication.

Literature analysis of 5 papers
Positive Content
4
Neutral Content
0
Negative Content
1
Article Type
1
4
3
3
5
1.

Effect of aliskiren, an oral direct renin inhibitor, on the pharmacokinetics and pharmacodynamics of a single dose of acenocoumarol in healthy volunteers.

Author: HuangH-L A, VaidyanathanS, YehC-M, BizotM-N, DieterichH A, DoleW P, HowardD

Aliskiren, a direct renin inhibitor for hypertension, had no clinically relevant effect on the pharmacokinetics or pharmacodynamics of a single dose of acenocoumarol in healthy volunteers.

Historical ArticleA research paper that analyzes past events and developments using primary sources and examines them from a historical perspective.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

Effect of aliskiren on cardiovascular outcomes in patients with prehypertension: a meta-analysis of randomized controlled trials.

Author: ZhangJing-Tao, ChenKe-Ping, GuanTing, ZhangShu

hypertension treatment

This meta-analysis evaluated the effects of aliskiren therapy on major cardiovascular outcomes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

3.

Renoprotection by Direct Renin Inhibition: A Systematic Review and Meta- Analysis.

Author: LouvisNikolaos, CoulsonJames

Reduced albuminuria
Renoprotection

This study assessed the renoprotective effects of aliskiren, a direct renin inhibitor. The authors found that aliskiren decreased albuminuria and proteinuria, suggesting that it may confer renoprotection by this mechanism. However, aliskiren did not appear to significantly change serum creatinine concentration (sCr) or estimated glomerular filtration rate (eGFR).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

4.

Effects of aliskiren on mortality, cardiovascular outcomes and adverse events in patients with diabetes and cardiovascular disease or risk: A systematic review and meta-analysis of 13,395 patients.

Author: ZhengSean L, RoddickAlistair J, AyisSalma

Hyperkalemia
Renal impairment

This meta-analysis investigated the efficacy and safety of aliskiren in patients with diabetes and increased cardiovascular risk or established cardiovascular disease. Aliskiren had no effect on all-cause mortality or combined cardiovascular mortality or heart failure hospitalization. However, patients receiving aliskiren had a greater risk of developing hyperkalemia and renal impairment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

5.

Clinical efficacy, safety and tolerability of aliskiren monotherapy: a protocol for an umbrella review.

Author: ZhaoQiyuan, ShenJiantong, LuJingya, LiFan, JiangQi, WangYuanyuan

Blood pressure reduction
Safety concerns

This paper systematically summarizes the published studies on the clinical efficacy and side effects of aliskiren monotherapy. Aliskiren, a renin-angiotensin-aldosterone system inhibitor, has been recognized for its role in lowering blood pressure. However, its safety and tolerability remain controversial.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

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