Effective treatment of aloe vera: A Synthesis of Findings from 15 Studies

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Original Abstract of the Article

Main Research Findings

Aloe vera has long been recognized for its medicinal properties, and recently, its potential benefits for various health concerns have gained attention. Studies suggest aloe vera is effective in treating burns ( 13 ), oral ulcers ( 15 ), improving symptoms of gastroesophageal reflux disease ( 7 ), improving electrocardiogram and blood pressure readings ( 3 ), improving mucocutaneous problems ( 8 ), treating ulcerative colitis ( 1 ), enhancing the effectiveness of influenza vaccines ( 12 ), treating chronic wounds ( 6 ), improving xerostomia ( 10 ), preventing radiation proctitis ( 9 ), improving periodontal parameters ( 11 ), improving liver fibrosis ( 5 ), improving gingivitis ( 4 ), improving pain and wound healing after hemorrhoidectomy ( 2 ), and even improving metabolic profiles in patients with type 2 diabetes and prediabetes ( 14 ).

However, it's important to note that the effectiveness of aloe vera is not yet fully understood, and its effects have been found to be inconsistent ( 14 ). Further research is needed to definitively establish its efficacy for specific conditions and symptoms.

Benefits and Risks

Benefit Summary

Aloe vera shows promise in a wide range of areas, including burns, oral ulcers, gastroesophageal reflux disease, electrocardiogram and blood pressure issues, mucocutaneous problems, ulcerative colitis, enhancing influenza vaccine effectiveness, treating chronic wounds, improving xerostomia, preventing radiation proctitis, improving periodontal parameters, improving liver fibrosis, improving gingivitis, improving pain and wound healing after hemorrhoidectomy, and even improving metabolic profiles in patients with type 2 diabetes and prediabetes. Aloe vera is also considered a safe treatment option due to its natural origin and low potential for side effects.

Risk Summary

While generally considered safe, aloe vera can rarely cause side effects. These side effects may include abdominal pain, diarrhea, and allergic reactions. Additionally, consuming aloe vera may lower blood sugar levels, so people with diabetes should be cautious. When using aloe vera, consult with a doctor and use appropriate amounts based on your health condition.

Comparison of Studies

Commonalities among Studies

Many studies suggest that aloe vera is potentially effective in various areas. It is also commonly acknowledged that aloe vera is a safe ingredient with a low risk of side effects.

Differences among Studies

Variations in study subjects, research design, types of aloe vera used, and evaluation methods contribute to inconsistencies in research findings. Therefore, more research is needed to provide a clearer picture of aloe vera's effectiveness.

Consistency and Contradictions in Results

Research findings on the effectiveness of aloe vera lack consistency. This is likely due to variations in study subjects, research design, types of aloe vera used, and evaluation methods. Therefore, further research is necessary to provide a more definitive assessment of aloe vera's effectiveness.

Cautions for Real-Life Applications

While aloe vera shows promise in various areas, it's important to remember that sufficient research has not yet been conducted, and its effectiveness remains inconsistent. Therefore, when using aloe vera, consulting with a doctor and using appropriate amounts based on your health condition is crucial. It's especially important to talk to your doctor before using aloe vera if you are pregnant, breastfeeding, taking medications, or have any pre-existing medical conditions.

Limitations of Current Research

Research on the effectiveness of aloe vera is still not comprehensive. In particular, there's a lack of research on long-term effects and the mechanisms by which aloe vera works. It's also possible that the effects of aloe vera vary depending on the type and preparation method.

Future Research Directions

To provide a more comprehensive understanding of aloe vera's effectiveness, the following research is needed:

  • Research on long-term effects
  • Research on the effects of aloe vera on various diseases
  • Research to understand the mechanisms underlying aloe vera's effectiveness
  • Research to determine whether the effects of aloe vera vary based on the type and preparation method

Conclusion

Aloe vera shows promise in various areas, but sufficient research has not yet been conducted, and its effectiveness remains inconsistent. Therefore, when using aloe vera, consulting with a doctor and using appropriate amounts based on your health condition is crucial.

Literature analysis of 15 papers
Positive Content
15
Neutral Content
0
Negative Content
0
Article Type
11
2
4
1
15
1.

Randomized, double-blind, placebo-controlled trial of oral aloe vera gel for active ulcerative colitis.

Author: LangmeadL, FeakinsR M, GoldthorpeS, HoltH, TsironiE, De SilvaA, JewellD P, RamptonD S

Aloe vera effective for ulcerative colitis
Aloe vera safe

Oral aloe vera was more effective than placebo in treating mildly to moderately active ulcerative colitis. Aloe vera also reduced histological disease activity.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

Effects of Aloe vera cream on posthemorrhoidectomy pain and wound healing: results of a randomized, blind, placebo-control study.

Author: EshghiFariborz, HosseinimehrSeyed Jalal, RahmaniNasrin, KhademlooMohammad, NoroziMohammad Sina, HojatiOmolbanin

Hemorrhoidectomy pain reduction
Wound healing

Application of Aloe vera cream on the surgical site is effective in reducing postoperative pain both on resting and during defecation, healing time, and analgesic requirements in the patients compared with the placebo group.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

Effects of oral Aloe vera on electrocardiographic and blood pressure measurements.

Author: ShahSachin A, DiTullioPatrick, AzadiMehdi, ShapiroRobert J, EidTony J, SnyderJeffrey A

A single dose of oral aloe vera has no effect on electrocardiographic or blood pressure measurements in young healthy volunteers.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

4.

Clinical and microbiologic effects of commercially available dentifrice containing aloe vera: a randomized controlled clinical trial.

Author: PradeepA R, AgarwalEsha, NaikSavitha B

Reduced inflammation
Reduced plaque

This clinical trial evaluated the clinical and microbiological effects of a dentifrice containing aloe vera on plaque reduction and gingival inflammation in patients with gingivitis.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

Antifibrotic effect of aloe vera in viral infection-induced hepatic periportal fibrosis.

Author: HegazySahar K, El-BedewyMohamed, YagiAkira

Anti-fibrotic effect
Anti-oxidative effect

Oral supplementation with aloe vera high molecular weight fractions (AHM) showed benefits in alleviating fibrosis and inflammation in hepatic fibrosis patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

6.

Comparative trial of Aloe vera/olive oil combination cream versus phenytoin cream in the treatment of chronic wounds.

Author: PanahiY, IzadiM, SayyadiN, RezaeeR, Jonaidi-JafariN, BeiraghdarF, ZamaniA, SahebkarA

AVO cream for wound healing

This study evaluates the effects of an Aloe vera-olive oil (AVO) combination cream on the healing process of chronic wounds. Aloe vera and olive oil are natural products with potential wound-healing properties.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

7.

Efficacy and safety of Aloe vera syrup for the treatment of gastroesophageal reflux disease: a pilot randomized positive-controlled trial.

Author: PanahiYunes, KhedmatHossein, ValizadeganGhasem, MohtashamiReza, SahebkarAmirhossein

GERD symptom relief
Safe
Well tolerated

Aloe vera syrup was found to be safe and effective in reducing the symptoms of gastroesophageal reflux disease (GERD). The study compared aloe vera to omeprazole and ranitidine and found that aloe vera was as effective as the other medications.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

8.

Effects of Aloe vera in adults with mucocutaneous problems: A systematic review and meta-analysis.

Author: Gok MetinZehra, HelvaciAylin, Gulbahar ErenMerve

Pain reduction
Wound healing

Aloe vera (AV) may have beneficial effects in reducing pain scores and the severity of mucocutaneous problems compared with placebo. A review of 23 studies found that AV accelerated tissue epithelialization and wound-healing process, reduced oral mucositis, and improved quality of life in some patients. However, more high quality and well-designed studies are needed to further elucidate the effects of AV in a variety of dosages and forms among adults with mucocutaneous problems.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

9.

Aloe vera for Prevention of Acute Radiation Proctitis in Colorectal Cancer a Preliminary Randomized, Placebo-Controlled Clinical Trial.

Author: SahebnasaghAdeleh, SaghafiFatemeh, GhasemiArash, AkbariJafar, AlipourAbbas, HabtemariamSolomon, SafdariMohammadreza, GhalenoHassan Rezai, SalehifarEbrahim

Improved psychosocial status
Improved quality of life
Reduced ARP severity
Reduced inflammation

This study found that topical Aloe vera 3% ointment reduced the severity of acute radiation proctitis (ARP) in colorectal cancer patients undergoing radiotherapy. Aloe vera treatment significantly improved symptoms of diarrhea and had positive effects on quality of life and psychosocial status. While toxicity measures did not reach statistical significance, the overall results suggest that Aloe vera may be beneficial for reducing ARP symptoms.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

10.

Comparison of the effect of ginger and aloe vera mouthwashes on xerostomia in patients with type 2 diabetes: A clinical trial, triple-blind.

Author: BadooeiF, ImaniE, Hosseini-TeshniziS, BanarM, MemarzadeM

Promotes oral health
Reduced xerostomia

Ginger and aloe vera mouthwashes were effective in reducing xerostomia in patients with diabetes. In a triple-blind study, both mouthwashes significantly decreased xerostomia symptoms and severity compared to normal saline.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

11.

Clinical Efficacy of Aloe Vera Toothpaste on Periodontal Parameters of Patients with Gingivitis-A Randomized, Controlled, Single-masked Clinical Trial.

Author: SayarFerena, FarahmandAmir H, RezazadehMaryam

Gingivitis treatment

Aloe vera toothpaste showed no significant improvement in dental plaque and gingivitis compared to fluoride toothpaste, suggesting it can be used as an alternative.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

12.

Effect of processed aloe vera gel on immunogenicity in inactivated quadrivalent influenza vaccine and upper respiratory tract infection in healthy adults: A randomized double-blind placebo-controlled trial.

Author: HwangJeong-Hwan, OhMi-Ra, HwangJi-Hyun, ChoiEun-Kyung, JungSu-Jin, SongEun-Jung, EspañoErica, WebbyRichard J, WebsterRobert G, KimJeong-Ki, ChaeSoo-Wan

Increased antibody response
Reduced URI incidence

Processed Aloe vera gel (PAG) did not significantly increase seroprotection rates from an immunogenicity perspective but reduced the number of upper respiratory tract infection (URI) episodes in healthy adults. Further studies are needed on PAG's effect on antibody response against influenza strains.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

14.

Effectiveness of aloe vera in patients with type 2 Diabetes Mellitus and pre-diabetes: An overview of systematic reviews.

Author: Araya-QuintanillaFelipe, Gutiérrez-EspinozaHéctor, Cuyul-VásquezIván, PavezLeonardo

Improved blood sugar
Reduced triglycerides

A systematic review of four systematic reviews assessed the effects of aloe vera on metabolic profiles. Moderate to high quality evidence suggested that aloe vera has beneficial effects in patients with type 2 diabetes (T2DM) and prediabetes, leading to reductions in fasting blood glucose, HbA1c, and triglycerides.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

15.

Effects of Aloe Vera in the Treatment of Oral Ulcers: A Systematic Review and Meta-Analysis of Randomised Controlled Trials.

Author: ZouHang, LiuZengjing, WangZhi, FangJuan

Oral ulcer healing
Pain relief
Reduced ulcer size

Aloe vera was associated with a better therapeutic effect and shorter healing time for oral ulcers compared to other interventions. It was comparable in relieving pain and reducing ulcer size but had higher safety and fewer side effects.

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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