Side Effects of amikacin oral inhalation: A Synthesis of Findings from 2 Studies

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Original Abstract of the Article

Major Research Findings

The study on aerosolized amikacin for the treatment of pulmonary Mycobacterium avium infections found that adding aerosolized amikacin to standard oral therapy might enhance treatment efficacy without causing systemic toxicity. 2

Reasons for Side Effects

Albendazole, an anthelmintic drug, is used globally for prophylactic or curative treatment. However, it can lead to various side effects such as diarrhea, abdominal pain, elevated levels of hepatic transaminases, dizziness, neutropenia, and alopecia. 1

Common Side Effects

Albendazole-Induced Liver Injury

Albendazole can cause liver injury, indicated by elevated levels of hepatic transaminases. 1

Gastrointestinal Symptoms

Albendazole can lead to gastrointestinal symptoms like diarrhea and abdominal pain. 1

Neurological Symptoms

Albendazole can cause neurological symptoms like dizziness. 1

Hematologic Disorders

Albendazole can cause hematologic disorders like neutropenia, a decrease in white blood cells. 1

Hair Loss

Albendazole can cause alopecia, hair loss. 1

Side Effect Management

Liver Injury Management

If liver injury symptoms arise, consult a doctor immediately. They may adjust the dosage or discontinue the medication.

Gastrointestinal Symptoms Management

If you experience gastrointestinal symptoms, consult your doctor for appropriate management strategies, which could include dietary adjustments or medication.

Neurological Symptoms Management

If you experience dizziness or other neurological symptoms, consult a doctor. They may adjust the dosage or discontinue the medication.

Hematologic Disorders Management

If you develop neutropenia or other hematologic disorders, consult a doctor. They may adjust the dosage or discontinue the medication.

Hair Loss Management

If hair loss is concerning, consult a doctor to explore potential treatment options.

Comparison between Studies

Commonalities

Both studies investigated the side effects associated with specific medications. 1 2

Differences

The drugs studied were different. 1 2

Implications for Daily Life

It is crucial to use amikacin oral inhalation as directed by your doctor. Do not self-medicate or stop taking the medication without consulting your doctor. If side effects occur, seek immediate medical attention.

Limitations of Current Research

Research on amikacin oral inhalation is limited in quantity, and long-term safety and efficacy remain unclear.

Future Research Directions

Further research is necessary to evaluate the long-term safety and efficacy of amikacin oral inhalation. Studies are also required to determine the optimal dosage and administration methods for this medication.

Conclusion

Amikacin oral inhalation may be an effective treatment for pulmonary Mycobacterium avium infections. However, due to the potential for side effects, it is essential to use this medication as instructed by a physician.

Keywords
Benefit Keywords
Antiparasitic treatment
1
mycobacterial tx
2
Risk Keywords
Liver injury
1
Literature analysis of 2 papers
Positive Content
1
Neutral Content
0
Negative Content
1
Article Type
0
0
1
0
2
1.

Albendazole-Induced Liver Injury.

Author: PiloiuClaudia, DumitrascuDan L

Antiparasitic treatment
Liver injury

Albendazole may induce liver injury, even in small doses, and practitioners and patients should be aware of this risk.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

2.

Aerosolized amikacin for treatment of pulmonary Mycobacterium avium infections: an observational case series.

Author: DavisKala K, KaoPeter N, JacobsSusan S, RuossStephen J

mycobacterial tx

This study assessed the safety, tolerability, and preliminary clinical benefits of adding aerosolized amikacin to a standard macrolide-based oral treatment regimen for nontuberculous mycobacterial pulmonary infection.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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