Side Effects of amivantamab-vmjw injection: A Synthesis of Findings from 3 Studies

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Original Abstract of the Article

Key Findings

Amitriptyline, reboxetine, and citalopram have all been associated with anticholinergic-like side effects (dry mouth, constipation, etc.) in therapeutic use, despite the very low antimuscarinic activity of reboxetine and citalopram in vitro. 2

Amitriptyline has been shown to cause side effects such as dry mouth, dizziness, subjective blood circulation-associated problems, and constipation in healthy adults. 3

Reasons for Side Effects

Amitriptyline, reboxetine, and citalopram can cause anticholinergic-like side effects because they affect the autonomic nervous system. Amitriptyline, in particular, is believed to affect the activity of the autonomic nervous system by inhibiting the reuptake of norepinephrine and serotonin. 2

Common Side Effects

Dry Mouth

Dry mouth has been reported with the use of amitriptyline. 3

Dizziness

Dizziness has been reported with the use of amitriptyline. 3

Subjective Blood Circulation-Associated Problems

Subjective blood circulation-associated problems have been reported with the use of amitriptyline. 3

Constipation

Constipation has been reported with the use of amitriptyline. 3

Managing Side Effects

Dry Mouth

To alleviate dry mouth, it is important to stay hydrated by drinking plenty of fluids. Chewing sugar-free gum or sucking on sugar-free candy can also be helpful.

Dizziness

If you experience dizziness, you should be careful when getting up or walking. It is also important to stay hydrated.

Subjective Blood Circulation-Associated Problems

Regular exercise and stretching can help to reduce subjective blood circulation-associated problems. Getting enough sleep is also important.

Constipation

To relieve constipation, it is important to eat a diet high in fiber. Staying hydrated is also important. If constipation persists, consult your doctor.

Comparison of Studies

Similarities

All studies have shown that amitriptyline can cause anticholinergic-like side effects. 2 3

Differences

Study 2 investigated the effects of amitriptyline, reboxetine, and citalopram on the autonomic nervous system, while study 3 investigated the placebo- and baseline-controlled side effects of amitriptyline.

Implications for Real-Life Applications

It is important to be aware of the potential for side effects such as dry mouth, dizziness, and constipation when taking amitriptyline. Staying hydrated, eating a balanced diet, and getting enough exercise can help to manage these side effects. Consult your doctor if you have any concerns about side effects.

Limitations of Current Research

Many studies on amitriptyline side effects have small sample sizes, and further research is needed. 3

Future Research Directions

New treatments and preventive measures are needed to reduce the side effects of amitriptyline. Further research is also needed on the long-term side effects of amitriptyline.

Conclusion

Amitriptyline can cause anticholinergic-like side effects, but with proper management and prevention, the risk of side effects can be minimized. If you have any concerns or questions about taking amitriptyline, consult your doctor.

Literature analysis of 3 papers
Positive Content
2
Neutral Content
1
Negative Content
0
Article Type
3
0
0
0
3
1.

Effects of desipramine, amitriptyline, and fluoxetine on pain in diabetic neuropathy.

Author: MaxM B, LynchS A, MuirJ, ShoafS E, SmollerB, DubnerR

Pain relief
Side effects

Desipramine was as effective as amitriptyline in relieving pain caused by diabetic neuropathy, offering an alternative for patients unable to tolerate amitriptyline.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

The effects of amitriptyline, citalopram and reboxetine on autonomic nervous system. A randomised placebo-controlled study on healthy volunteers.

Author: PenttiläJ, SyvälahtiE, HinkkaS, KuuselaT, ScheininH

Anticholinergic side effects

Reboxetine, despite its low antimuscarinic activity in vitro, had distinct effects on the HF power of RRI, consistent with anticholinergic activity in vivo. Amitriptyline had a measurable anticholinergic effect in the salivary glands, but not in the heart.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

Assessment of adverse events in clinical drug trials: Identifying amitriptyline's placebo- and baseline-controlled side effects.

Author: RhekerJulia, RiefWinfried, DoeringBettina K, WinklerAlexander

Structured harm assessment
Blood circulation problems
Constipation
Dizziness
Dry mouth

Adverse events in clinical drug trials are often poorly assessed and reported. A study of 40 healthy individuals who were randomized to either amitriptyline or placebo found that the amitriptyline group reported significantly more complaints of dry mouth, dizziness, subjective blood circulation-associated problems, and constipation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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