Effects of atropine ophthalmic: A Synthesis of Findings from 13 Studies

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Original Abstract of the Article

Major Research Findings

Bisoprolol is a beta-blocker that has been studied extensively for its effects on heart failure and hypertension. 11 、 6 、 3 、 4 、 8 Research suggests that bisoprolol can effectively lower heart rate and blood pressure, both at rest and during physical activity. 6 、 3 Additionally, bisoprolol has shown potential benefits in improving exercise tolerance and reducing myocardial damage. 9 、 7 、 13 However, there are some potential side effects, including possible impact on sexual function. 1 Furthermore, certain doses of bisoprolol might influence lipid metabolism. 10 Research exploring the relationship between bisoprolol dosage and efficacy is available in 3 and 7 . Comparisons between bisoprolol and other beta-blockers have been conducted, 12 、 8 revealing bisoprolol's potential for greater selectivity on the heart and enhanced exercise tolerance compared to other beta-blockers. 2 、 5 、 13

Benefits and Risks

Benefits Summary

Bisoprolol has demonstrated its ability to lower heart rate and blood pressure. 6 、 3 Additionally, it has shown potential for improving exercise tolerance and reducing myocardial damage. 9 、 7 、 13 These benefits can contribute to improving symptoms associated with heart failure and hypertension.

Risks Summary

Bisoprolol may potentially impact sexual function. 1 Furthermore, certain doses of bisoprolol might influence lipid metabolism. 10 Bisoprolol can interact with other medications, so it's crucial to consult with a healthcare professional before starting bisoprolol therapy.

Comparison Across Studies

Commonalities

Across multiple studies, a consistent finding is that bisoprolol effectively lowers heart rate and blood pressure. 6 、 3 、 4 、 8 There is a general consensus that bisoprolol is beneficial for managing heart failure and hypertension. 11 、 6 、 3 、 4 、 13

Differences

Variations exist in research findings regarding bisoprolol dosage and side effects. 10 、 1 Comparisons between bisoprolol and other beta-blockers have indicated that different medications might lead to varying effects and side effects. 12 、 8

Consistency and Contradictions

Numerous studies consistently demonstrate bisoprolol's effectiveness in reducing heart rate and blood pressure. 6 、 3 、 4 、 8 However, discrepancies in research findings regarding bisoprolol dosage and side effects necessitate further investigation. 10 、 1

Real-World Application Considerations

While bisoprolol is an effective medication for managing heart failure and hypertension, it might affect sexual function. 1 Additionally, bisoprolol can interact with other medications, so it's essential to consult with a healthcare professional before starting bisoprolol therapy. 2

Current Research Limitations

Long-term effects and safety data regarding bisoprolol are still insufficient. 3 Further research is required to fully understand the relationship between bisoprolol dosage and side effects. 10

Future Research Directions

Further research is needed to thoroughly investigate the long-term effects and safety of bisoprolol. 3 Additionally, studies exploring the relationship between bisoprolol dosage and side effects, along with its interactions with other medications, are crucial. 10

Conclusion

Bisoprolol is a beta-blocker that has shown potential benefits in managing heart failure and hypertension. 11 、 6 、 3 、 4 、 13 It is important to consult with a healthcare professional to discuss the potential benefits and risks of bisoprolol and to determine the most appropriate treatment approach for your individual needs. 2

Literature analysis of 13 papers
Positive Content
13
Neutral Content
0
Negative Content
0
Article Type
13
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13
1.

Bisoprolol and hypertension: effects on sexual functioning in men.

Author: BroekmanC P, HaenselS M, Van de VenL L, SlobA K

Improved sexuality

Bisoprolol is an effective antihypertensive drug with no detrimental effects on sexuality in newly diagnosed men with hypertension. In men already on antihypertensive medication, bisoprolol improved certain aspects of sexuality.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

A metabolic assessment of the beta 1 selectivity of bisoprolol.

Author: HaffnerC A, HortonR C, LewisH M, HughesB, KendallM J

Effective antianginal
Effective antihypertensive
Minimal effect on beta 2 receptors
Decreasing beta 1 selectivity

Bisoprolol, a beta-blocker, had comparable beta1 selectivity to atenolol as measured by metabolic response. At a dose of 5 mg, bisoprolol had minimal effect on beta2 receptors.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

Dose-effect relationship and long-term effects of bisoprolol in mild to moderate hypertension.

Author: WeinerL, FrithzG

Blood pressure reduction
Heart rate reduction
Cold extremities

Bisoprolol, a new beta 1-selective beta-blocking agent, was effective in reducing blood pressure and heart rate in 48 hypertensive patients. The 20 mg dose was more effective than the 5 or 10 mg doses. The effects were sustained over 10 months of treatment. Side effects were common but mild.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

Double-blind comparison of the cardioselective beta-blockers bisoprolol and atenolol in hypertension: the Bisoprolol International Multicenter Study (BIMS).

Author: BühlerF R, BerglundG, AndersonO K, BrunnerH R, ScherrerU, van BrummelenP, DistlerA, PhilippT, FogariR, MimranA

Blood pressure reduction
Well-being

Bisoprolol was found to be slightly but significantly more effective than atenolol in lowering blood pressure in 94 patients with essential hypertension. Bisoprolol also resulted in higher rates of achieving diastolic target pressures of less than or equal to 95 mm Hg. Both drugs were well-tolerated.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

Beta 1-adrenoceptor selectivity of single oral doses of bisoprolol and atenolol.

Author: ChangP C, van VeenS, van der KrogtJ A, VermeijP, van BrummelenP

More potent than atenolol
Selective beta 1 antagonists

Bisoprolol and atenolol were both selective beta 1 antagonists, with bisoprolol showing slightly more potency and selectivity.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

6.

Antihypertensive effects of bisoprolol during once daily administration in patients with essential hypertension. A dose-ranging study with parallel groups.

Author: WeinerL, FrithzG

Effective for hypertension
Well-tolerated

Bisoprolol, a new beta 1-selective beta-blocking agent, was effective in treating essential hypertension.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

7.

Comparison of the effects of two doses of bisoprolol on exercise tolerance in exercise-induced stable angina pectoris.

Author: de MuinckE, WagnerG, vd VenL L, LieK I

Improved exercise tolerance
Longer duration of action

Bisoprolol, a beta-blocker, was found to improve exercise tolerance in patients with coronary heart disease. A 10mg dose was more effective than a 5mg dose, but both doses had a duration of action lasting over 24 hours.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

8.

Exercise blood pressure and heart rate reduction 24 and 3 hours after drug intake in hypertensive patients following 4 weeks of treatment with bisoprolol and metoprolol: a randomized multicentre double-blind study (BISOMET).

Author: HaasisR, BethgeH

Lower blood pressure
Lower heart rate
Persistent reduction in blood pressure

Bisoprolol and metoprolol, two beta-blockers, were compared for their effects on blood pressure and heart rate during exercise. Bisoprolol showed significantly stronger and more persistent effects on blood pressure and heart rate throughout the 24-hour dosage interval compared to metoprolol.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

9.

Relationships between acute and chronic beta-blocking effects of bisoprolol in healthy volunteers: a practical approach to predict intensity of beta-blockade.

Author: JaminP, LeCozF, Funck-BrentanoC, PoirierJ M, JaillonP

Beta-blockade prediction
Chronic ischemia treatment

Bisoprolol-induced beta-blockade after repeated oral dosing can be predicted by single-test i.v. dose administration.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

10.

Effects of small doses of bisoprolol on blood pressure and lipoprotein concentrations in hypertensive patients.

Author: LithellH, WeinerL, VessbyB, NordströmM L

Blood pressure reduction
Cholesterol reduction
Hypertension treatment

Bisoprolol is a drug that is used to treat high blood pressure. This study found that bisoprolol, at a low dose (2.5 mg per day), was equally effective as a higher dose (5 mg per day) at lowering blood pressure. Both doses had small effects on lipid levels, with an unexpected decrease in LDL cholesterol.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

11.

Prognostic value of bisoprolol-induced hemodynamic effects in heart failure during the Cardiac Insufficiency BIsoprolol Study (CIBIS).

Author: LechatP, EscolanoS, GolmardJ L, LardouxH, WitchitzS, HennemanJ A, MaischB, HetzelM, JaillonP, BoisselJ P, MalletA

Improved survival
Preserved left ventricular function

Preservation of left ventricular function played a key role in the beneficial effects of bisoprolol therapy in heart failure, with heart rate change and left ventricular fractional shortening change over time being predictive of survival.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

12.

Comparing beta-blocking effects of bisoprolol, carvedilol and nebivolol.

Author: StoschitzkyKurt, StoschitzkyGergana, BrusseeHelmut, BonelliClaudia, DobnigHarald

Improved QOL
Reduced heart rate
Sleep disturbances

Bisoprolol, carvedilol, and nebivolol all effectively reduce heart rate, but they have distinct effects on peak and trough beta-blocking activity and nocturnal melatonin release. Bisoprolol exhibits stronger peak beta-blocking effects, while nebivolol has the highest trough-to-peak ratio. Only bisoprolol significantly reduced nocturnal melatonin release, potentially leading to sleep disturbances.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

13.

Protective effects of bisoprolol against myocardial injury and pulmonary dysfunction in patients with chronic heart failure.

Author: ToyodaShigeru, HaruyamaAkiko, InamiShu, AmanoHirohisa, ArikawaTakuo, SakumaMasashi, AbeShichiro, TanakaAtsushi, NodeKoichi, InoueTeruo

Myocardial protection
Preserved pulmonary function
None reported

In 67 patients with chronic systolic heart failure, bisoprolol showed possible superiority to carvedilol in protecting against myocardial injury and preserving pulmonary function. Bisoprolol lowered troponin T levels and improved forced expiratory volume compared to carvedilol.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

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